PADB-logoLSSR - molecule cluster A8712CISD2, CDGSH2, ERISCDGSH iron sulfur domain-containing protein 2

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensCISD2_HUMANQ8N5K113515278604928, 611507

Functions and Classifications

GOC:endoplasmic reticulum membrane, C:integral component of membrane, C:mitochondrial outer membrane, C:protein complex, F:2 iron, 2 sulfur cluster binding, F:metal ion binding, F:protein homodimerization activity, P:mitochondrion degradation, P:multicellular organismal aging, P:regulation of autophagy, "C:endoplasmic reticulum, F:2 iron, 2 sulfur cluster binding", C:integral to membrane, C:intracellular membrane-bounded organelle
UniProt2Fe-2S, 3D-structure, Autophagy, Complete proteome, Deafness, Diabetes mellitus, Direct protein sequencing, Endoplasmic reticulum, Iron, Iron-sulfur, Membrane, Metal-binding, Mitochondrion, Mitochondrion outer membrane, Reference proteome, Transmembrane, Transmembrane helix
PADBMOD: modulator, regulator


percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   0.88 
16861337humanblooderythrocytenot mentionedhealthy     Identified peptides: 8
15905145ratkidneyinner medullary collecting duct (IMCD) Isolation of AQP-2 containing intracellular vesicles     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
15593129ratkidneyrenal cortex, brush border membrane vesicles healthy     
17000643ratliverinner mitochondrial membrane healthy     
16615899mouseliverorganelle healthy     
15684408mouseplasma membranebrain cortex and hippocampus healthy     

Compile date 12-23-2014© PADB initiative