PADB-logoLSSR - molecule cluster A8201XDH, XDHAXanthine dehydrogenase/oxidase

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensXDH_HUMANP479891332146293278300, 607633

Functions and Classifications

GOC:cytosol, C:extracellular region, C:peroxisome, F:2 iron, 2 sulfur cluster binding, F:electron carrier activity, F:flavin adenine dinucleotide binding, F:iron ion binding, F:molybdopterin cofactor binding, F:UDP-N-acetylmuramate dehydrogenase activity, F:xanthine dehydrogenase activity, F:xanthine oxidase activity, P:activation of cysteine-type endopeptidase activity involved in apoptotic process, P:lactation, P:negative regulation of endothelial cell differentiation, P:negative regulation of endothelial cell proliferation, P:negative regulation of gene expression, P:negative regulation of protein kinase B signaling, P:negative regulation of protein phosphorylation, P:negative regulation of vascular endothelial growth factor signaling pathway, P:negative regulation of vasculogenesis, P:positive regulation of p38MAPK cascade, P:positive regulation of reactive oxygen species metabolic process, P:purine nucleotide catabolic process, P:xanthine catabolic process, "F:flavin adenine dinucleotide binding, F:oxidoreductase activity, acting on CH-OH group of donors, P:regulation of epithelial cell differentiation", P:negative regulation of protein kinase B signaling cascade
UniProt2Fe-2S, 3D-structure, Complete proteome, Cytoplasm, Disease mutation, Disulfide bond, FAD, Flavoprotein, Glycoprotein, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD, Oxidoreductase, Peroxisome, Polymorphism, Reference proteome, Secreted
PADBENZ: enzyme, enzymatic properties

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
50000002120680012

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
14692452humanurinewhole healthy     
16684767humanbloodplasma severe trauma     Identified peptides: 1
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   1.035 
16452116humanmultipleperoxisome healthy     detection: database trawling 
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17768142mousekidneyperoxisome healthy       
16615899mouseliverorganelleRecycling endosomes (RE/TGN)|Cytosol (Cyto)healthy     

Compile date 12-23-2014© PADB initiative