PADB-logoLSSR - molecule cluster A8135UBR4, RBAF600, ZUBR1E3 ubiquitin-protein ligase UBR4

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensUBR4_HUMANQ5T4S75184573939609890

Functions and Classifications

GOC:cytoplasm, C:cytoskeleton, C:integral component of membrane, C:nucleus, F:ubiquitin-protein ligase activity, F:zinc ion binding, P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process, P:viral process, F:ligase activity, P:metabolic process, C:integral to membrane, F:metal ion binding, P:virus-host interaction
UniProtAcetylation, Alternative splicing, Calmodulin-binding, Complete proteome, Cytoplasm, Cytoskeleton, Direct protein sequencing, Host-virus interaction, Ligase, Membrane, Metal-binding, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Transmembrane, Transmembrane helix, Ubl conjugation pathway, Zinc, Zinc-finger
PADBENZ: enzyme, enzymatic properties

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16684767humanbloodplasma severe trauma     Identified peptides: 3
21616181mousecornea  lumican knock-out   1.01 
16861337humanblooderythrocytecytoplasmichealthy     
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 3
14532281ratbrainPSD forebrain healthy     
16047384ratbrainPSD pre- and postsynapse (cortex)presynaptichealthy     Sequence coverage: 0.4
15951573humanlungbronchoalveolar lavage asthma     
15684408mouseplasma membranebrain cortex and hippocampus healthy     
21127740humanurinewhole acute abdominal pain     Identified peptides: 2

Compile date 12-23-2014© PADB initiative