PADB-logoLSSR - molecule cluster A7916FARSLA, FARSA, FARSPhenylalanyl-tRNA synthetase alpha chain

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensSYFA_HUMANQ9Y28550857564602918

Functions and Classifications

GOC:cytosol, F:ATP binding, F:phenylalanine-tRNA ligase activity, F:tRNA binding, P:phenylalanyl-tRNA aminoacylation, P:tRNA aminoacylation for protein translation, C:cytoplasm, F:aminoacyl-tRNA ligase activity, P:tRNA aminoacylation
UniProt3D-structure, Acetylation, Aminoacyl-tRNA synthetase, ATP-binding, Complete proteome, Cytoplasm, Direct protein sequencing, Ligase, Nucleotide-binding, Phosphoprotein, Polymorphism, Protein biosynthesis, Reference proteome
PADBENZ: enzyme, enzymatic properties

Expression

ratios [in mouse]
cytosol/nucleusheart/brainkidney/brainliver/brain
50   
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
0000000000100000

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   1.485 
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 6
16615899mouseliverorganelleRecycling endosomes (RE/TGN)healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        

Compile date 12-23-2014© PADB initiative