PADB-logoLSSR - molecule cluster A7557ADSL, AMPSAdenylosuccinate lyase

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensPUR8_HUMANP3056648454889103050, 608222

Functions and Classifications

GOC:cytosol, C:mitochondrion, F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity, F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity, P:'de novo' AMP biosynthetic process, P:'de novo' IMP biosynthetic process, P:aerobic respiration, P:AMP biosynthetic process, P:protein tetramerization, P:purine nucleobase metabolic process, P:response to hypoxia, P:response to muscle activity, P:response to nutrient, P:response to starvation, "C:cytoplasm, P:purine ribonucleotide biosynthetic process", "F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity, C:cytosol, P:response to nutrient", F:lyase activity, P:purine ribonucleotide biosynthetic process
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Direct protein sequencing, Disease mutation, Epilepsy, Lyase, Purine biosynthesis, Reference proteome
PADBENZ: enzyme, enzymatic properties

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
21616181mousecornea  lumican knock-out   0.865 
17172703humanmultiplemitochondriaMitochondrialhealthy     detection: high confidence prediction (Mitopred)confidence %: 100
16861337humanblooderythrocytecytoplasmichealthy     Identified peptides: 1
23308193humanbladder cancer cell linecytosolic and nuclear fractionation bladder cancer   0.7 
UNPUBLISHED_2humanliverwhole, fetal healthy     

Compile date 12-23-2014© PADB initiative