PADB-logoLSSR - molecule cluster A7518PSMA1, HC2, NUProteasome subunit alpha type 1

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensPSA1_HUMANP2578626329556602854

Functions and Classifications

GOC:centrosome, C:cytosol, C:nucleoplasm, C:polysome, C:proteasome core complex, C:proteasome core complex, alpha-subunit complex, F:RNA binding, F:threonine-type endopeptidase activity, P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, P:apoptotic process, P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, P:G1/S transition of mitotic cell cycle, P:gene expression, P:mRNA metabolic process, P:negative regulation of apoptotic process, P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:protein polyubiquitination, P:regulation of cellular amino acid metabolic process, P:small molecule metabolic process, P:viral process, "C:cytoplasm, C:nucleus, P:ubiquitin-dependent protein catabolic process", C:centrosome, P:proteolysis involved in cellular protein catabolic process, F:lipopolysaccharide binding, P:M/G1 transition of mitotic cell cycle, P:negative regulation of inflammatory response to antigenic stimulus, P:regulation of apoptotic process, P:S phase of mitotic cell cycle, P:viral reproduction"
UniProtAcetylation, Alternative splicing, Complete proteome, Cytoplasm, Direct protein sequencing, Glycoprotein, Hydrolase, Immunity, Isopeptide bond, Nucleus, Phosphoprotein, Polymorphism, Protease, Proteasome, Reference proteome, Threonine protease, Ubl conjugation
PADBENZ: enzyme, enzymatic properties

Expression

ratios [in mouse]
cytosol/nucleusheart/brainkidney/brainliver/brain
8.7   
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
0000000000000100

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
18501002mousekidneycortexCytoplasmhealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 12
16709260humansemenplasma healthy     
16901338humantearwhole healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   1.66 
16861337humanblooderythrocytecytoplasmichealthy     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
16691549ratliverGolgi healthy      
16615899mouseliverorganelleProteasome (PS)healthy     
15951573humanlungbronchoalveolar lavage asthma     
15684408mouseplasma membranebrain cortex and hippocampus healthy     
15064947humantestiswhole healthy     
18582094mousetestiswhole healthy     
21127740humanurinewhole acute abdominal pain     Identified peptides: 1
18578523humanPC3 cancer cellsecretion       
UNPUBLISHED_3humanPC3 cancer cellwhole        
18553995humanprostatewhole prostate cancer     Identified peptides: 5
20334419humanprostateprostate secretion healthy     
19056867humanurineexosome healthy     Identified peptides: 2

Compile date 12-23-2014© PADB initiative