PADB-logoLSSR - molecule cluster A742CLRG1, LRGLeucine-rich alpha-2-glycoprotein precursor

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensA2GL_HUMANP0275034738178611289

Functions and Classifications

GOC:extracellular space, C:membrane, P:brown fat cell differentiation
UniProtComplete proteome, Direct protein sequencing, Disulfide bond, Glycoprotein, Leucine-rich repeat, Polymorphism, Reference proteome, Repeat, Secreted, Signal
PADBUK: unknown

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
0000000000000100

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
16316981humanurinewhole healthy     
17723740humanurinewhole healthy     
16684767humanbloodplasma severe trauma     Identified peptides: 35
16709260humansemenplasma healthy     
16901338humantearwhole healthy     
18361515humansalivaParotid;SMSL healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
16740002humansalivawhole healthy     
21616181mousecornea  lumican knock-out   0.555 
15951573humanlungbronchoalveolar lavage asthma     
17044913humanlungbronchoalveolar lavage lung fibrosis   1  
15473691humansalivawhole healthy     Unique peptides: 2
11680902humanurinewhole healthy     
17022654humanurinewhole healthy     
17022654humanurinewhole healthy     
17327332humanurinewhole Diabetic Nephropathy     
15048996humanurinewholeplasmahealthy     
15048996humanurinewholeplasmahealthy     
17143626humanurinewhole IgA nephropathy (IgAN) associated with Hodgkin’s disease in children and Rx treatment (CHOP chemotherapy (cyclophosphamide, vincristine, doxorubicin, prednisone, Enalapril))   0.26  
17494094humanurinewhole healthy; tubular proteinuria (TP), X-linked form of renal Fanconi syndrome; Dent's disease, X-linked form of renal Fanconi syndrome; Lowe disease, X-linked form of renal Fanconi syndrome; autosomal dominant idiopathic form (ADIF) of renal Fanconi syndrome   1.3 
16281181humanurinewhole healthy     
15140760humanurinewhole Dent's disease   >1 Identified peptides: 1
17518487humanurinewholesecreted protein bladder cancer     
16335936humanurinewhole healthy     
18373357humanurinemicroparticles bladder cancer   1.1 
18440303raturineglycoproteins glomerular disease/adriamycin nephropathy and Thy1.1 glomerulonephritis   3.00
21127740humanurinewhole acute abdominal pain     Identified peptides: 608
21538913humanurinewhole cancer (upper GI)     
UNPUBLISHED_1humanurinewhole healthy, cancer     
18578523humanPC3 cancer cellsecretion       
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
20334419humanprostateprostate secretion healthy     

Compile date 12-23-2014© PADB initiative