PADB-logoLSSR - molecule cluster A7357PEPD, PRDXaa-Pro dipeptidase

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensPEPD_HUMANP1295549254417170100, 613230

Functions and Classifications

GOF:aminopeptidase activity, F:dipeptidase activity, F:manganese ion binding, F:metallocarboxypeptidase activity, P:cellular amino acid metabolic process, P:collagen catabolic process, P:proteolysis, P:metabolic process, P:cellular process, F:hydrolase activity
UniProt3D-structure, Acetylation, Alternative splicing, Collagen degradation, Complete proteome, Dipeptidase, Direct protein sequencing, Disease mutation, Hydrolase, Manganese, Metal-binding, Metalloprotease, Polymorphism, Protease, Reference proteome
PADBENZ: enzyme, enzymatic properties

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
600000000688000

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
17723740humanurinewhole healthy     
16684767humanbloodplasma severe trauma     Identified peptides: 19
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   1.01 
16861337humanblooderythrocytecytoplasmichealthy     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
16449382ratkidneyinner medullary collecting duct (IMCD) 3 day Vasopressin infusion to Brattleboro rat   0.39 
17711322humankidneyglomerulus healthy     
15951573humanlungbronchoalveolar lavage asthma     
17022654humanurinewhole healthy     
21127740humanurinewhole acute abdominal pain     Identified peptides: 16
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
19056867humanurineexosome healthy     Identified peptides: 1

Compile date 12-23-2014© PADB initiative