PADB-logoLSSR - molecule cluster A6891GLO1Lactoylglutathione lyase

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensLGUL_HUMANQ0476018320588138750

Functions and Classifications

GOC:cytoplasm, F:lactoylglutathione lyase activity, F:zinc ion binding, P:carbohydrate metabolic process, P:glutathione metabolic process, P:methylglyoxal metabolic process, P:negative regulation of apoptotic process, P:osteoclast differentiation, P:regulation of transcription from RNA polymerase II promoter, F:metal ion binding
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Direct protein sequencing, Disulfide bond, Glutathionylation, Lyase, Metal-binding, Phosphoprotein, Polymorphism, Reference proteome, Zinc
PADBENZ: enzyme, enzymatic properties

Expression

ratios [in mouse]
cytosol/nucleusheart/brainkidney/brainliver/brain
21   
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
2530151001000005050

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
18501002mousekidneycortexCytoplasmhealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 3
16709260humansemenplasma healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   0.86 
16861337humanblooderythrocytecytoplasmichealthy     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
16615899mouseliverorganelleCytosol (Cyto)healthy     
15951573humanlungbronchoalveolar lavage asthma     
16021519humanovarywhole healthy     
18582094mousetestiswhole healthy     
18373357humanurinemicroparticles bladder cancer   0.8 
21127740humanurinewhole acute abdominal pain     Identified peptides: 2
18578523humanPC3 cancer cellsecretion       
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
18553995humanprostatewhole prostate cancer     Identified peptides: 4
20334419humanprostateprostate secretion healthy     
19056867humanurineexosome healthy     Identified peptides: 1

Compile date 12-23-2014© PADB initiative