PADB-logoLSSR - molecule cluster A6823AK2, ADK2Adenylate kinase 2, mitochondrial

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensKAD2_HUMANP5481923926478103020, 267500

Functions and Classifications

GOC:cytosol, C:mitochondrial inner membrane, C:mitochondrial intermembrane space, C:sperm mitochondrial sheath, F:adenylate kinase activity, F:ATP binding, P:ADP biosynthetic process, P:AMP metabolic process, P:ATP metabolic process, P:brain development, P:dATP metabolic process, P:liver development, P:nucleobase-containing small molecule interconversion, P:oxidative phosphorylation, P:response to thyroid hormone, F:nucleobase-containing compound kinase activity, P:nucleobase-containing compound metabolic process, P:nucleotide phosphorylation, P:AMP salvage
UniProt3D-structure, Acetylation, Alternative splicing, ATP-binding, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Kinase, Mitochondrion, Nucleotide-binding, Polymorphism, Reference proteome, Transferase
PADBENZ: enzyme, enzymatic properties

Expression

ratios [in rat]
cytosol/nucleusheart/brainkidney/brainliver/brain
 1.171.671.85
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
4, 43, 33, 32, 24, 415, 151, 11, 117, 173, 313, 136, 616, 1611, 11

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
18501002mousekidneycortexCytoplasmhealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 2
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
15253431humanheartmitochondria healthy     Unique peptides: 1
15253431humanheartmitochondria healthy     Unique peptides: 3
21616181mousecornea  lumican knock-out   0.96 
16928776ratbrain;heart;kidney;livermitochondria healthy      
15668995humankidneycortex healthy     
15668995humankidneycortex healthy     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
17000643ratliverinner mitochondrial membrane healthy     
16615899mouseliverorganelleMitochondrion (Mito)|Recycling endosomes (RE/TGN)|Cytosol (Cyto)healthy     
15951573humanlungbronchoalveolar lavage asthma     
18578523humanPC3 cancer cellsecretion       
18578523humanPC3 cancer cellsecretion       
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
18553995humanprostatewhole prostate cancer     Identified peptides: 7

Compile date 12-23-2014© PADB initiative