PADB-logoLSSR - molecule cluster A6813IVDIsovaleryl-CoA dehydrogenase, mitochondrial precursor

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensIVD_HUMANP2644042346319243500, 607036

Functions and Classifications

GOC:mitochondrial matrix, F:flavin adenine dinucleotide binding, F:isovaleryl-CoA dehydrogenase activity, P:cellular nitrogen compound metabolic process, P:leucine catabolic process, F:acyl-CoA dehydrogenase activity, C:mitochondrial membrane, P:oxidation-reduction process
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Direct protein sequencing, Disease mutation, FAD, Flavoprotein, Mitochondrion, Oxidoreductase, Reference proteome, Transit peptide
PADBENZ: enzyme, enzymatic properties

Expression

ratios [in rat]
cytosol/nucleusheart/brainkidney/brainliver/brain
 1.261.341.23
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
322315965151255127

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
18501002mousekidneycortexCytoplasmhealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 1
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   0.985 
17172703humanmultiplemitochondriaMitochondrialhealthy     detection: high confidence prediction (Mitopred)confidence %: 100
16928776ratbrain;heart;kidney;livermitochondria healthy      
17436268mousekidneycortex diabetes   0.5 
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
17711322humankidneyglomerulus healthy     
15593129ratkidneyrenal cortex, brush border membrane vesicles healthy     
16615899mouseliverorganelleMitochondrion (Mito)healthy     
15064947humantestiswhole healthy     
18582094mousetestiswhole healthy     
18563753ratheartmitochondria spontaneous hypertension   1.15 +/- 0.10*** 
UNPUBLISHED_3humanPC3 cancer cellwhole        

Compile date 12-23-2014© PADB initiative