PADB-logoLSSR - molecule cluster A6642GPX1Glutathione peroxidase 1

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensGPX1_HUMANP0720320322088138320

Functions and Classifications

GOC:cytosol, C:mitochondrion, C:nucleus, F:glutathione binding, F:glutathione peroxidase activity, F:phospholipid-hydroperoxide glutathione peroxidase activity, F:selenium binding, P:aging, P:angiogenesis involved in wound healing, P:arachidonic acid metabolic process, P:blood vessel endothelial cell migration, P:cell redox homeostasis, P:endothelial cell development, P:fat cell differentiation, P:glutathione metabolic process, P:heart contraction, P:hydrogen peroxide catabolic process, P:interaction with symbiont, P:intrinsic apoptotic signaling pathway in response to oxidative stress, P:lipoxygenase pathway, P:myoblast proliferation, P:negative regulation of apoptotic process, P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, P:negative regulation of inflammatory response to antigenic stimulus, P:negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress, P:negative regulation of release of cytochrome c from mitochondria, P:positive regulation of protein kinase B signaling, P:protein oxidation, P:purine nucleobase metabolic process, P:purine nucleotide catabolic process, P:regulation of gene expression, epigenetic, P:regulation of mammary gland epithelial cell proliferation, P:regulation of neuron apoptotic process, P:regulation of proteasomal protein catabolic process, P:response to estradiol, P:response to folic acid, P:response to gamma radiation, P:response to glucose, P:response to lipid hydroperoxide, P:response to nicotine, P:response to selenium ion, P:response to symbiotic bacterium, P:response to toxic substance, P:response to xenobiotic stimulus, P:sensory perception of sound, P:skeletal muscle fiber development, P:skeletal muscle tissue regeneration, P:temperature homeostasis, P:triglyceride metabolic process, P:UV protection, P:vasodilation, P:vasodilation, P:response to oxidative stress, F:endopeptidase inhibitor activity, P:induction of apoptosis, P:myotube differentiation, P:positive regulation of protein kinase B signaling cascade, P:release of cytochrome c from mitochondria, P:response to hydroperoxide, P:response to toxin
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Cytoplasm, Oxidoreductase, Peroxidase, Polymorphism, Reference proteome, Selenocysteine, Selenium
PADBENZ: enzyme, enzymatic properties

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
371314270111104748

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
18501002mousekidneycortexCytoplasmhealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 4
16901338humantearwhole healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   1.01 
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 2
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
15593129ratkidneyrenal cortex, basolateral membrane vesicles healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
17000643ratliverinner mitochondrial membrane healthy     
16691549ratliverGolgi healthy      
16615899mouseliverorganelleCytosol (Cyto)healthy     
15951573humanlungbronchoalveolar lavage asthma     
15064947humantestiswhole healthy     
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
18563753ratheartmitochondria spontaneous hypertension   1.55 +/- 0.10*** 
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
18553995humanprostatewhole prostate cancer     Identified peptides: 2

Compile date 12-23-2014© PADB initiative