PADB-logoLSSR - molecule cluster A6100COX4I1, COX4Cytochrome c oxidase subunit IV isoform 1, mitochondrial precursor

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensCOX41_HUMANP1307316919577123864

Functions and Classifications

GOC:mitochondrial inner membrane, C:nucleus, F:cytochrome-c oxidase activity, P:respiratory electron transport chain, P:response to nutrient, P:small molecule metabolic process, P:ion transmembrane transport, P:oxidation-reduction process, P:proton transport
UniProtAcetylation, Complete proteome, Direct protein sequencing, Membrane, Mitochondrion, Mitochondrion inner membrane, Polymorphism, Reference proteome, Transit peptide
PADBENZ: enzyme, enzymatic properties

Expression

ratios [in rat]
cytosol/nucleusheart/brainkidney/brainliver/brain
 1.441.110.87
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
88776568678877

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
18501002mousekidneycortexCytoplasmhealthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
15253431humanheartmitochondria healthy     Unique peptides: 2
15253431humanheartmitochondria healthy     Unique peptides: 7
21616181mousecornea  lumican knock-out   0.975 
17172703humanmultiplemitochondriaMitochondrialhealthy     detection: high confidence prediction (Mitopred)confidence %: 100
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 4
15852343ratbrainPSD cerebral cortex (frontal) healthy     Sequence coverage: 6.98
16928776ratbrain;heart;kidney;livermitochondria healthy      
12724530humanHela cell extractlipid raftspH-resistant raft; detergent-resistant rafthealthy      
15905145ratkidneyinner medullary collecting duct (IMCD) Isolation of AQP-2 containing intracellular vesicles     
15593129ratkidneyrenal cortex, brush border membrane vesicles healthy     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
15593129ratkidneyrenal cortex, brush border membrane vesicles healthy     
17711322humankidneyglomerulus healthy     
17000643ratliverinner mitochondrial membrane healthy     
16615899mouseliverorganelleMitochondrion (Mito)healthy     
15684408mouseplasma membranebrain cortex and hippocampus healthy     
21127740humanurinewhole acute abdominal pain     Identified peptides: 10
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
18563753ratheartmitochondria spontaneous hypertension   1.12 +/- 0.11** 
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        

Compile date 12-23-2014© PADB initiative