PADB-logoLSSR - molecule cluster A5410NESNestin

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensNEST_HUMANP486811621177439600915

Functions and Classifications

GOC:cytoplasm, C:intermediate filament, F:intermediate filament binding, F:structural molecule activity, P:brain development, P:cell projection morphogenesis, P:embryonic camera-type eye development, P:G2/M transition of mitotic cell cycle, P:negative regulation of catalytic activity, P:negative regulation of neuron apoptotic process, P:negative regulation of protein binding, P:positive regulation of intermediate filament depolymerization, P:positive regulation of neural precursor cell proliferation, P:stem cell proliferation, C:intermediate filament cytoskeleton, P:nervous system development, P:negative regulation of apoptotic process, P:response to drug, P:response to ionizing radiation, P:response to nutrient levels
UniProtCoiled coil, Complete proteome, Developmental protein, Intermediate filament, Neurogenesis, Phosphoprotein, Polymorphism, Reference proteome
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
910651075134468710

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16684767humanbloodplasma severe trauma     Identified peptides: 1
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   1.97 
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
21127740humanurinewhole acute abdominal pain     Identified peptides: 22
18578523humanPC3 cancer cellsecretion       
UNPUBLISHED_3humanPC3 cancer cellwhole        
18553995humanprostatewhole prostate cancer     Identified peptides: 17

Compile date 12-23-2014© PADB initiative