PADB-logoLSSR - molecule cluster A5250WDR1, PNAS-29WD-repeat containing protein 1

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensWDR1_HUMANO7508360666193604734

Functions and Classifications

GOC:cell junction, C:cell projection, C:cytosol, C:extracellular region, C:podosome, P:platelet activation, P:platelet degranulation, P:sensory perception of sound, C:cytoskeleton
UniProtAcetylation, Actin-binding, Alternative splicing, Cell junction, Cell projection, Complete proteome, Cytoplasm, Cytoskeleton, Direct protein sequencing, Phosphoprotein, Polymorphism, Reference proteome, Repeat, WD repeat
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Expression

ratios [in mouse]
cytosol/nucleusheart/brainkidney/brainliver/brain
22   
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
242820000000350011

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
18501002mousekidneycortexUnknownhealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 27
16684767humanbloodplasma severe trauma     Identified peptides: 28
16901338humantearwhole healthy     
18361515humansalivaParotid healthy     Identified peptides: 4
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   1.15 
17172703humanmultiplemitochondriaMitochondrialhealthy     detection: high confidence prediction (Mitopred)confidence %: 99
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 2
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
16449382ratkidneyinner medullary collecting duct (IMCD) 3 day Vasopressin infusion to Brattleboro rat   1.69 
16449382ratkidneyinner medullary collecting duct (IMCD) IMCD vs. non-IMCD protein amounts   1.71 0.33 
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
16615899mouseliverorganelleRecycling endosomes (RE/TGN)|Plasma membrane (PM)|Cytosol (Cyto)healthy     
15951573humanlungbronchoalveolar lavage asthma     
16021519humanovarywhole healthy     
15064947humantestiswhole healthy     
15064947humantestiswhole healthy     
21127740humanurinewhole acute abdominal pain     Identified peptides: 28
UNPUBLISHED_1humanurinewhole cancer     
18578523humanPC3 cancer cellsecretion       
18578523humanPC3 cancer cellsecretion       
23308193humanbladder cancer cell linecytosolic and nuclear fractionation bladder cancer   0.99 
UNPUBLISHED_3humanPC3 cancer cellwhole        
18553995humanprostatewhole prostate cancer     Identified peptides: 9
20334419humanprostateprostate secretion healthy     
19056867humanurineexosome healthy     Identified peptides: 4
19056867humanurineexosome healthy     Identified peptides: 10

Compile date 12-23-2014© PADB initiative