PADB-logoLSSR - molecule cluster A5153SPTBN2, SCA5Spectrin beta chain, brain 2

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensSPTN2_HUMANO150202390271295600224, 604985, 615386

Functions and Classifications

GOC:cytosol, C:neuronal cell body, C:spectrin, F:actin binding, F:phospholipid binding, F:structural constituent of cytoskeleton, P:actin filament capping, P:adult behavior, P:antigen processing and presentation of exogenous peptide antigen via MHC class II, P:axon guidance, P:cell death, P:cerebellar Purkinje cell layer morphogenesis, P:multicellular organism growth, P:synapse assembly, P:vesicle-mediated transport, P:synaptic vesicle exocytosis
UniProt3D-structure, Acetylation, Actin capping, Actin-binding, Alternative splicing, Complete proteome, Cytoplasm, Cytoskeleton, Disease mutation, Neurodegeneration, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Spinocerebellar ataxia
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
01455140000141419140

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
16507876ratbrainPSD (forebrain and cerebellum) healthy     Identified peptides: 6
21616181mousecornea  lumican knock-out   0.995 
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 87
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
16047384ratbrainPSD pre- and postsynapse (cortex)pre- and postsynaptichealthy     Sequence coverage: 3.3
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15905145ratkidneyinner medullary collecting duct (IMCD) Isolation of AQP-2 containing intracellular vesicles     
16449382ratkidneyinner medullary collecting duct (IMCD) 3 day Vasopressin infusion to Brattleboro rat   1.64 0.07 
16641100ratkidneyinner medullary collecting duct (IMCD) Phosphoproteome of IMCD     
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
15593129ratkidneyrenal cortex, brush border membrane vesicles healthy     
15593129ratkidneyrenal cortex, basolateral membrane vesicles healthy     
15593129ratkidneyrenal cortex, brush border membrane vesicles healthy     
15593129ratkidneyrenal cortex, basolateral membrane vesicles healthy     
15593129ratkidneyrenal cortex, brush border membrane vesicles healthy     
15593129ratkidneyrenal cortex, brush border membrane vesicles healthy     
16615899mouseliverorganelle healthy     
15684408mouseplasma membranebrain cortex and hippocampus healthy     
20198343humanurinewhole cancer -weight losing     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     

Compile date 12-23-2014© PADB initiative