PADB-logoLSSR - molecule cluster A493AH2AFX, H2AXHistone H2A.x

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensH2AX_HUMANP1610414215013601772

Functions and Classifications

GOC:condensed nuclear chromosome, C:male germ cell nucleus, C:nuclear chromatin, C:nucleoplasm, C:nucleosome, C:replication fork, C:site of double-strand break, C:XY body, F:damaged DNA binding, F:DNA binding, P:DNA damage checkpoint, P:double-strand break repair via homologous recombination, P:meiosis, P:nucleosome assembly, P:positive regulation of DNA repair, P:response to ionizing radiation, P:spermatogenesis
UniProt3D-structure, Acetylation, Cell cycle, Chromosome, Complete proteome, DNA damage, DNA recombination, DNA repair, DNA-binding, Isopeptide bond, Meiosis, Nucleosome core, Nucleus, Phosphoprotein, Reference proteome, Ubl conjugation
PADBTF: transcription and translation, gene regulation

Expression

ratios [in mouse]
cytosol/nucleusheart/brainkidney/brainliver/brain
0.01   
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
04000406148470612

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16446289humanhairshaft healthy     
18361515humansalivaSMSL healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   0.85 
15169875rat; mousebrainPSD (whole brain) healthy     
17711322humankidneyglomerulus healthy     
16615899mouseliverorganelleGolgi|ER/Golgi vesicles (ERGDV)|Nucleushealthy     
21538913humanurinewhole cancer (upper GI)     
UNPUBLISHED_1humanurinewhole healthy, cancer     
UNPUBLISHED_3humanPC3 cancer cellwhole        

Compile date 12-23-2014© PADB initiative