PADB-logoLSSR - molecule cluster A3991MTDH, AEG1, LYRICProtein Lyric

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensLYRIC_HUMANQ86UE458263837610323

Functions and Classifications

GOC:apical plasma membrane, C:endoplasmic reticulum membrane, C:integral component of membrane, C:intercellular canaliculus, C:nuclear body, C:nuclear membrane, C:nucleolus, C:perinuclear region of cytoplasm, C:tight junction, F:double-stranded RNA binding, F:transcription coactivator activity, P:lipopolysaccharide-mediated signaling pathway, P:negative regulation of apoptotic process, P:negative regulation of transcription from RNA polymerase II promoter, P:positive regulation of angiogenesis, P:positive regulation of autophagy, P:positive regulation of I-kappaB kinase/NF-kappaB signaling, P:positive regulation of NF-kappaB transcription factor activity, P:positive regulation of protein kinase B signaling, P:tight junction assembly, C:endoplasmic reticulum, C:integral to membrane, P:positive regulation of I-kappaB kinase/NF-kappaB cascade, P:positive regulation of protein kinase B signaling cascade
UniProtCell junction, Complete proteome, Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Tight junction, Transmembrane, Transmembrane helix
PADBTM: transmembrane

Expression

ratios [in mouse]
cytosol/nucleusheart/brainkidney/brainliver/brain
0.15   
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
0000010000000000

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
18501002mousekidneycortexCytoplasmhealthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   0.995 
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 6
16635246mousebrainPSD (forebrain) healthy      
12724530humanHela cell extractlipid raftspH-resistant raft; detergent-resistant rafthealthy      
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
16641100ratkidneyinner medullary collecting duct (IMCD) Phosphoproteome of IMCD     
17711322humankidneyglomerulus healthy     
16615899mouseliverorganelleNucleushealthy     
15684408mouseplasma membranebrain cortex and hippocampus healthy     
23308193humanbladder cancer cell linecytosolic and nuclear fractionation bladder cancer   0.37 
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        

Compile date 12-23-2014© PADB initiative