PADB-logoLSSR - molecule cluster A3918VCPTransitional endoplasmic reticulum ATPase

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensTERA_HUMANP5507280689322167320, 601023, 613954

Functions and Classifications

GOC:cytosol, C:endoplasmic reticulum, C:lipid particle, C:nucleus, C:proteasome complex, C:site of double-strand break, F:ADP binding, F:ATP binding, F:ATPase activity, F:lipid binding, F:polyubiquitin binding, P:activation of cysteine-type endopeptidase activity involved in apoptotic process, P:aggresome assembly, P:double-strand break repair, P:endoplasmic reticulum unfolded protein response, P:ER to Golgi vesicle-mediated transport, P:ER-associated ubiquitin-dependent protein catabolic process, P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process, P:positive regulation of protein complex assembly, P:protein homooligomerization, P:protein N-linked glycosylation via asparagine, P:protein ubiquitination, P:retrograde protein transport, ER to cytosol, P:translesion synthesis, C:cytosol, C:protein complex, P:ubiquitin-dependent protein catabolic process, F:nucleoside-triphosphatase activity, P:metabolic process, C:cytoplasm, P:ER-associated protein catabolic process
UniProt3D-structure, Acetylation, Amyotrophic lateral sclerosis, ATP-binding, Complete proteome, Cytoplasm, Direct protein sequencing, Disease mutation, DNA damage, DNA repair, Endoplasmic reticulum, Hydrolase, Lipid-binding, Methylation, Neurodegeneration, Nucleotide-binding, Nucleus, Phosphoprotein, Reference proteome, Transport, Ubl conjugation, Ubl conjugation pathway
PADBENZ: enzyme, enzymatic properties

Expression

ratios [in mouse]
cytosol/nucleusheart/brainkidney/brainliver/brain
1.5   
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
89184052933172713

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
18501002mousekidneycortexCytoplasmhealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 10
16709260humansemenplasma healthy     
17381150humannasalolfactory cleft mucus (nasal mucus) healthy     
16901338humantearwhole healthy     
16446289humanhairshaft healthy     
18361515humansalivaParotid;SMSL healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   1.035 
21616181mousecornea  lumican knock-out   1.21 
16861337humanblooderythrocytecytoplasmichealthy     Identified peptides: 6
16635246mousebrainPSD (forebrain) healthy      
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 12
15852343ratbrainPSD cerebral cortex (frontal) healthy     Sequence coverage: 4.76
12724530humanHela cell extractlipid raftsdetergent-resistant raft; Raft protein; Membrane proteinhealthy      
15905145ratkidneyinner medullary collecting duct (IMCD) Isolation of AQP-2 containing intracellular vesicles     
16449382ratkidneyinner medullary collecting duct (IMCD) 3 day Vasopressin infusion to Brattleboro rat   1.48 0.38 
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
16691549ratliverGolgi healthy      
16691549ratliverGolgi healthy      
16615899mouseliverorganelleCytosol (Cyto)healthy     
15951573humanlungbronchoalveolar lavage asthma     
16021519humanovarywhole healthy     
16021519humanovarywhole healthy     
15064947humantestiswhole healthy     
18582094mousetestiswhole healthy     
18582094mousetestiswhole healthy     
18582094mousetestiswhole healthy     
18582094mousetestiswhole healthy     
18582094mousetestiswhole healthy     
21127740humanurinewhole acute abdominal pain     Identified peptides: 8
UNPUBLISHED_1humanurinewhole cancer     
18578523humanPC3 cancer cellsecretion       
23308193humanbladder cancer cell linecytosolic and nuclear fractionation bladder cancer   0.92 
23376485humanurinepodocyte healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
18553995humanprostatewhole prostate cancer     Identified peptides: 18
20334419humanprostateprostate secretion healthy     
19056867humanurineexosome healthy     Identified peptides: 2
15732135ratheartright ventricles pulmonary hypertension  down0.476190476 
18725486mouselungwhole lung pulmonary hypertension   4.2 

Compile date 12-23-2014© PADB initiative