PADB-logoLSSR - molecule cluster A3851KRT75, K6HF, KB18Keratin, type II cytoskeletal 75

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensK2C75_HUMANO9567855159504600628, 609025, 612318

Functions and Classifications

GOC:keratin filament, F:structural molecule activity
UniProtCoiled coil, Complete proteome, Disease mutation, Intermediate filament, Keratin, Polymorphism, Reference proteome, Phosphoprotein
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
200011922917414453

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
18361515humansalivaParotid;SMSL healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   0 
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
15593129ratkidneyrenal cortex, brush border membrane vesicles healthy     
16691549ratliverGolgi healthy      
16615899mouseliverorganellePlasma membrane (PM)healthy     
15684408mouseplasma membranebrain cortex and hippocampus healthy     
18373357humanurinemicroparticles bladder cancer   1.5 
21127740humanurinewhole acute abdominal pain     Identified peptides: 366
UNPUBLISHED_1humanurinewhole healthy, cancer     
23376485humanurinepodocyte healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        

Compile date 12-23-2014© PADB initiative