PADB-logoLSSR - molecule cluster A3680GLUD1, GLUDGlutamate dehydrogenase 1, mitochondrial precursor

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensDHE3_HUMANP0036755861398138130, 606762

Functions and Classifications

GOC:mitochondrial matrix, F:ADP binding, F:ATP binding, F:glutamate dehydrogenase (NAD+) activity, F:glutamate dehydrogenase [NAD(P)+] activity, F:GTP binding, F:identical protein binding, F:leucine binding, F:NAD+ binding, P:cellular nitrogen compound metabolic process, P:glutamate biosynthetic process, P:glutamate catabolic process, P:glutamine metabolic process, P:positive regulation of insulin secretion, P:tricarboxylic acid metabolic process, "C:mitochondrion, F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor, P:cellular amino acid metabolic process", F:oxidoreductase activity, P:cellular amino acid metabolic process, "F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor, C:mitochondrion, F:nucleotide binding, "F:nucleotide binding
UniProt3D-structure, Acetylation, ADP-ribosylation, ATP-binding, Complete proteome, Direct protein sequencing, Disease mutation, GTP-binding, Mitochondrion, NADP, Nucleotide-binding, Oxidoreductase, Phosphoprotein, Reference proteome, Transit peptide
PADBENZ: enzyme, enzymatic properties

Expression

ratios [in rat]
cytosol/nucleusheart/brainkidney/brainliver/brain
 0.67, 0.711.03, 0.981.76, 2.62
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
7, 88, 712, 1111, 104, 613, 111, 12, 26, 66, 615, 154, 52, 210, 9

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
18501002mousekidneycortexCytoplasmhealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 24
17381150humannasalolfactory cleft mucus (nasal mucus) healthy     
18361515humansalivaParotid healthy     Identified peptides: 4
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
16507876ratbrainPSD (forebrain and cerebellum) healthy     Identified peptides: 1
15020595ratbrainPSD (forebrain) healthy     
21616181mousecornea  lumican knock-out   1.06 
17172703humanmultiplemitochondriaMitochondrialhealthy     detection: high confidence prediction (Mitopred)confidence %: 100
14720225ratbrainPSD forebrain healthy      
16635246mousebrainPSD (forebrain) healthy      
14532281ratbrainPSD forebrain healthy     
14532281ratbrainPSD forebrain healthy     
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 32
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
19455133mousebrainPSD95-associated proteins healthy     Identified peptides: 5
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
16047384ratbrainPSD pre- and postsynapse (cortex)postsynaptichealthy     Sequence coverage: 15.6
16332460ratbrainPSD (hippocampus) healthy     Identified peptides: 2
16928776ratbrain;heart;kidney;livermitochondria healthy      
16928776ratbrain;heart;kidney;livermitochondria healthy      
15668995humankidneycortex healthy     
15668995humankidneycortex healthy     
15668994humankidneyglomerulus healthy     
15668994humankidneyglomerulus healthy     
15668994humankidneyglomerulus healthy     
15668994humankidneyglomerulus healthy     
18167449ratkidneywhole diabetes     
17436268mousekidneycortex diabetes   2.4 
16449382ratkidneyinner medullary collecting duct (IMCD) 3 day Vasopressin infusion to Brattleboro rat   0.55 0.07 
16449382ratkidneyinner medullary collecting duct (IMCD) IMCD vs. non-IMCD protein amounts   2.04 
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
17474143mousekidneyperoxisomesMitochondrialhealthy     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
17768142mousekidneyperoxisomemitochondrialhealthy     
15593129ratkidneyrenal cortex, basolateral membrane vesicles healthy     
15593129ratkidneyrenal cortex, brush border membrane vesicles healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
17000643ratliverinner mitochondrial membrane healthy     
17474143mouseliverperoxisomesMitochondrialhealthy     
16615899mouseliverorganelleMitochondrion (Mito)healthy     
15684408mouseplasma membranebrain cortex and hippocampus healthy     
15064947humantestiswhole healthy     
18582094mousetestiswhole healthy     
21127740humanurinewhole acute abdominal pain     Identified peptides: 9
23308193humanbladder cancer cell linecytosolic and nuclear fractionation bladder cancer   0.79 
18563753ratheartmitochondria spontaneous hypertension   1.37 +/- 0.15* 
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
18553995humanprostatewhole prostate cancer     Identified peptides: 11

Compile date 12-23-2014© PADB initiative