PADB-logoLSSR - molecule cluster A3661IDH1, PICDIsocitrate dehydrogenase [NADP] cytoplasmic

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensIDHC_HUMANO7587441446659137800, 147700

Functions and Classifications

GOC:cytosol, C:mitochondrion, C:peroxisomal matrix, F:isocitrate dehydrogenase (NADP+) activity, F:magnesium ion binding, F:NAD binding, F:NADP binding, P:2-oxoglutarate metabolic process, P:cellular lipid metabolic process, P:female gonad development, P:glutathione metabolic process, P:glyoxylate cycle, P:isocitrate metabolic process, P:NADPH regeneration, P:response to oxidative stress, P:response to steroid hormone, P:tricarboxylic acid cycle, C:peroxisome
UniProt3D-structure, Acetylation, Complete proteome, Cytoplasm, Direct protein sequencing, Glyoxylate bypass, Magnesium, Manganese, Metal-binding, NADP, Oxidoreductase, Peroxisome, Polymorphism, Reference proteome, Tricarboxylic acid cycle
PADBENZ: enzyme, enzymatic properties

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
00005635531419326

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
18501002mousekidneycortexCytoplasmhealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 13
16709260humansemenplasma healthy     
17381150humannasalolfactory cleft mucus (nasal mucus) healthy     
16901338humantearwhole healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   0.8 
16452116humanmultipleperoxisome healthy     detection: database trawling 
15936593humanbladder cancer cell linewhole early and late stages of bladder cancer  downregulated  
17436268mousekidneycortex diabetes     
12965894ratkidneyinner medullary collecting duct (IMCD) IMCD vs. non-IMCD protein amounts     
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
12234301ratkidneyCortex;Medulla healthy      
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
17768142mousekidneyperoxisomal membranecytoplasmic, peroxisomalhealthy     
17768142mousekidneyperoxisomecytoplasmic, peroxisomalhealthy     
17768142mousekidneyperoxisomecytoplasmix, peroxisomalhealthy     
17768142mousekidneyperoxisomecytoplasmichealthy     
17768142mousekidneyperoxisomecytoplasmic, peroxisomalhealthy     
15593129ratkidneyrenal cortex, basolateral membrane vesicles healthy     
15593129ratkidneyrenal cortex, brush border membrane vesicles healthy     
14561759ratliverperoxisomeperoxisomalhealthy     
16691549ratliverGolgi healthy      
16615899mouseliverorganelleMitochondrion (Mito)|Cytosol (Cyto)healthy     
15951573humanlungbronchoalveolar lavage asthma     
16816363humanlungbronchoalveolar lavageCellular, cytosol, peroxisomeacute respiratory distress syndrome     Unique peptides: 15
18334958humantearwholecytoplasmhealthy      
15064947humantestiswhole healthy     
18582094mousetestiswhole healthy     
15596215humanurinewhole prostate cancer     
15326289humanurineexosomecytoplasmhealthy     
18373357humanurinemicroparticles bladder cancer   0.9 
21127740humanurinewhole acute abdominal pain     Identified peptides: 45
UNPUBLISHED_1humanurinewhole cancer     
18578523humanPC3 cancer cellsecretion       
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
20334419humanprostateprostate secretion healthy     
18553995humanprostatewhole prostate cancer     Identified peptides: 8
19056867humanurineexosome healthy     Identified peptides: 14

Compile date 12-23-2014© PADB initiative