PADB-logoLSSR - molecule cluster A3568PSMD126S proteasome non-ATPase regulatory subunit 1

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensPSMD1_HUMANQ99460953105866 

Functions and Classifications

GOC:cytosol, C:nucleoplasm, C:proteasome regulatory particle, F:enzyme regulator activity, P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, P:apoptotic process, P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, P:G1/S transition of mitotic cell cycle, P:gene expression, P:mRNA metabolic process, P:negative regulation of apoptotic process, P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:protein polyubiquitination, P:regulation of cellular amino acid metabolic process, P:regulation of protein catabolic process, P:small molecule metabolic process, P:viral process, C:proteasome complex, P:regulation of catalytic activity, P:M/G1 transition of mitotic cell cycle, P:regulation of apoptotic process, P:S phase of mitotic cell cycle, P:viral reproduction"
UniProtAcetylation, Alternative splicing, Complete proteome, Phosphoprotein, Proteasome, Reference proteome, Repeat
PADBUK: unknown

Expression

ratios [in mouse]
cytosol/nucleusheart/brainkidney/brainliver/brain
4.1   
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
3300000000067000

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16901338humantearwhole healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   1.07 
16861337humanblooderythrocytecytoplasmichealthy     
16635246mousebrainPSD (forebrain) healthy      
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
16615899mouseliverorganelle healthy     
21127740humanurinewhole acute abdominal pain     Identified peptides: 2
23308193humanbladder cancer cell linecytosolic and nuclear fractionation bladder cancer   0.99 
23376485humanurinepodocyte healthy     

Compile date 12-23-2014© PADB initiative