PADB-logoLSSR - molecule cluster A3541TCP1, CCT1, CCTAT-complex protein 1, alpha subunit

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensTCPA_HUMANP1798755660344186980

Functions and Classifications

GOC:acrosomal vesicle, C:cell body, C:cell junction, C:centrosome, C:chaperonin-containing T-complex, C:cytosol, C:Golgi apparatus, C:microtubule, C:nuclear heterochromatin, C:nucleus, C:pericentriolar material, C:plasma membrane, C:zona pellucida receptor complex, F:ATP binding, F:unfolded protein binding, P:'de novo' posttranslational protein folding, P:binding of sperm to zona pellucida, P:tubulin complex assembly, P:protein folding, C:cytoplasm
UniProtAcetylation, ATP-binding, Chaperone, Complete proteome, Cytoplasm, Cytoskeleton, Direct protein sequencing, Nucleotide-binding, Phosphoprotein, Polymorphism, Reference proteome
PADBCHA: chaperone, chaperonin

Expression

ratios [in mouse]
cytosol/nucleusheart/brainkidney/brainliver/brain
14   
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
661160000001103328

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
18501002mousekidneycortexCytoplasmhealthy     
16709260humansemenplasma healthy     
18361515humansalivaSMSL healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   0.96 
16861337humanblooderythrocytecytoplasmichealthy     
11895482mousebrainPSD forebrain healthy  concentration increase   
16635246mousebrainPSD (forebrain) healthy      
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 19
18536710drosohila (fruit fly)headPDZ-affinity peptide healthy     Identified peptides: 8
12724530humanHela cell extractlipid raftsdetergent-resistant raft; Membrane proteinhealthy      
12724530humanHela cell extractlipid raftsdetergent-resistant rafthealthy      
17436268mousekidneycortex diabetes   2.9 
12965894ratkidneyinner medullary collecting duct (IMCD) IMCD vs. non-IMCD protein amounts     
16079266ratkidneyinner medullary collecting duct (IMCD) Vasopressin escape in rat     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
15593129ratkidneyrenal cortex, brush border membrane vesicles healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
16691549ratliverGolgi healthy      
16615899mouseliverorganelleEndoplasmic reticulum (ER)|ER/Golgi vesicles (ERGDV)|Recycling endosomes (RE/TGN)healthy     
15378748mouselungbronchoalveolar lavage asthma (dex-sensitised and challenged)   1.5 
16816363humanlungbronchoalveolar lavageCellular, cytosolacute respiratory distress syndrome     Unique peptides: 3
16021519humanovarywhole healthy     
15684408mouseplasma membranebrain cortex and hippocampus healthy     
18582094mousetestiswhole healthy     
15529407humanurinewhole healthy     
21127740humanurinewhole acute abdominal pain     Identified peptides: 4
18578523humanPC3 cancer cellsecretion       
23308193humanbladder cancer cell linecytosolic and nuclear fractionation bladder cancer   1.52 
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
18553995humanprostatewhole prostate cancer     Identified peptides: 5
20334419humanprostateprostate secretion healthy     
19056867humanurineexosome healthy     Identified peptides: 2
19056867humanurineexosome healthy     Identified peptides: 1

Compile date 12-23-2014© PADB initiative