PADB-logoLSSR - molecule cluster A2536NCLNucleolin

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensNUCL_HUMANP1933871076614164035

Functions and Classifications

GOC:cell cortex, C:nucleolus, C:nucleoplasm, C:ribonucleoprotein complex, F:nucleotide binding, F:RNA binding, F:telomeric DNA binding, P:angiogenesis, F:nucleic acid binding
UniProt3D-structure, Acetylation, Complete proteome, Cytoplasm, Direct protein sequencing, DNA-binding, Methylation, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Repeat, RNA-binding
PADBTF: transcription and translation, gene regulation

Expression

ratios [in mouse]
cytosol/nucleusheart/brainkidney/brainliver/brain
0.73   
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
0000000000100000

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
18501002mousekidneycortexNucleushealthy     
18361515humansalivaSMSL healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   0.975 
12176931humanHela cell extractspliceosome healthy      
12724530humanHela cell extractlipid raftsdetergent-resistant raft; Raft protein; Membrane proteinhealthy      
16381850humanHela cell extractnucleus healthy     theoretical Mr: 51383
16381850humanHela cell extractnucleus healthy     theoretical Mr: 76355
16381850humanHela cell extractnucleus healthy     theoretical Mr: 74337
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
16615899mouseliverorganelleEndoplasmic reticulum (ER)|Recycling endosomes (RE/TGN)|Plasma membrane (PM)healthy     
18582094mousetestiswhole healthy     
21127740humanurinewhole acute abdominal pain     Identified peptides: 1
18578523humanPC3 cancer cellsecretion       
18578523humanPC3 cancer cellsecretion       
18578523humanPC3 cancer cellsecretion       
23308193humanbladder cancer cell linecytosolic and nuclear fractionation bladder cancer   1.07 
23376485humanurinepodocyte healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
18553995humanprostatewhole prostate cancer     Identified peptides: 11

Compile date 12-23-2014© PADB initiative