PADB-logoLSSR - molecule cluster A1672COL4A4Collagen alpha 4(IV) chain precursor

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensCO4A4_HUMANP534201690164096120131, 141200, 203780

Functions and Classifications

GOC:basal lamina, C:collagen type IV, C:endoplasmic reticulum lumen, F:extracellular matrix structural constituent, P:axon guidance, P:collagen catabolic process, P:extracellular matrix disassembly, P:glomerular basement membrane development, C:collagen
UniProtAlport syndrome, Basement membrane, Collagen, Complete proteome, Deafness, Disease mutation, Disulfide bond, Extracellular matrix, Glycoprotein, Hydroxylation, Polymorphism, Reference proteome, Repeat, Secreted, Signal
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
21616181mousecornea  lumican knock-out   3.38 
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
16372274humanurinewholeCell surfaceImmunoglobulin A nephropathy (IgAN)   52 

Compile date 12-23-2014© PADB initiative