PADB-logoLSSR - molecule cluster A1611HRGHistidine-rich glycoprotein precursor

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensHRG_HUMANP0419652559578142640, 613116

Functions and Classifications

GOC:extracellular region, C:plasma membrane, C:platelet alpha granule lumen, F:cysteine-type endopeptidase inhibitor activity, F:heme binding, F:heparan sulfate proteoglycan binding, F:heparin binding, F:immunoglobulin binding, F:receptor binding, F:serine-type endopeptidase inhibitor activity, F:zinc ion binding, P:angiogenesis, P:chemotaxis, P:defense response to fungus, P:fibrinolysis, P:negative regulation of angiogenesis, P:negative regulation of blood vessel endothelial cell migration, P:negative regulation of cell adhesion mediated by integrin, P:negative regulation of cell growth, P:negative regulation of cell proliferation, P:negative regulation of endopeptidase activity, P:negative regulation of endothelial cell chemotaxis, P:negative regulation of fibrinolysis, P:negative regulation of lamellipodium assembly, P:negative regulation of vascular endothelial growth factor signaling pathway, P:platelet activation, P:platelet degranulation, P:positive regulation of apoptotic process, P:positive regulation of blood vessel remodeling, P:positive regulation of focal adhesion assembly, P:positive regulation of immune response to tumor cell, P:regulation of actin cytoskeleton organization, P:regulation of gene expression, P:regulation of peptidyl-tyrosine phosphorylation, P:regulation of platelet activation, P:regulation of protein complex assembly, F:cell surface binding, F:metal ion binding
UniProtAngiogenesis, Blood coagulation, Chemotaxis, Cleavage on pair of basic residues, Complete proteome, Copper, Direct protein sequencing, Disease mutation, Disulfide bond, Fibrinolysis, Glycoprotein, Hemostasis, Heparin-binding, Metal-binding, Polymorphism, Reference proteome, Repeat, Secreted, Signal, Thrombophilia, Zinc
PADBMOD: modulator, regulator

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
0000014000000086

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
16684767humanbloodplasma severe trauma     Identified peptides: 70
16684767humanbloodplasma severe trauma     Identified peptides: 2
18361515humansalivaSMSL healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   0.625 
16691549ratliverGolgi healthy      
16691549ratliverGolgi healthy      
16615899mouseliverorganelleRecycling endosomes (RE/TGN)healthy     
15951573humanlungbronchoalveolar lavage asthma     
11680902humanurinewhole healthy     
17518487humanurinewholesecreted protein bladder cancer     
16335936humanurinewhole healthy     
21127740humanurinewhole acute abdominal pain     Identified peptides: 43
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
20334419humanprostateprostate secretion healthy     
19056867humanurineexosome healthy     Identified peptides: 2

Compile date 12-23-2014© PADB initiative