PADB-logoLSSR - molecule cluster A1599CFH, HF, HF1Complement factor H precursor

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensCFAH_HUMANP086031231139125126700, 134370, 235400, 609814, 610698

Functions and Classifications

GOC:extracellular space, F:heparan sulfate proteoglycan binding, F:heparin binding, P:complement activation, P:complement activation, alternative pathway, P:innate immune response, P:regulation of complement activation
UniProt3D-structure, Age-related macular degeneration, Alternative splicing, Complement alternate pathway, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Glycoprotein, Hemolytic uremic syndrome, Immunity, Innate immunity, Polymorphism, Reference proteome, Repeat, Secreted, Signal, Sushi
PADBDIS: disease

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
0, 00, 00, 03, 00, 00, 00, 019, 403, 00, 06, 00, 00, 069, 60

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
17494094humanurinewhole healthy; Dent's disease, X-linked form of renal Fanconi syndrome; Lowe disease, X-linked form of renal Fanconi syndrome     
18501002mousekidneycortexExtracellular Spacehealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 249
16684767humanbloodplasma severe trauma     Identified peptides: 58
16901338humantearwhole healthy     
16901338humantearwhole healthy     
18361515humansalivaParotid;SMSL healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   1.01 
17627911ratbloodserum bone loss model (associated with extended bed rest or space travel) by Hindlimb unloading   0.39 
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
16691549ratliverGolgi healthy      
16615899mouseliverorganelleER/Golgi vesicles (ERGDV)healthy     
15951573humanlungbronchoalveolar lavage asthma     
16819730humanlungsputum       
16865190humantearwhole healthy     
11680902humanurinewhole healthy     
17327332humanurinewhole Diabetic Nephropathy     
15140760humanurinewhole Dent's disease   24+/-0.33 Identified peptides: 2
17518487humanurinewholesecreted protein bladder cancer     
16335936humanurinewhole healthy     
21127740humanurinewhole acute abdominal pain     Identified peptides: 12
UNPUBLISHED_1humanurinewhole cancer     
18578523humanPC3 cancer cellsecretion       
18553995humanprostatewhole prostate cancer     Identified peptides: 11
20334419humanprostateprostate secretion healthy     
19056867humanurineexosome healthy     Identified peptides: 1
22199233ratbloodplasma Chagasic cardiomyopathy     
22199233ratbloodplasma Chagasic cardiomyopathy     

Compile date 12-23-2014© PADB initiative