PADB-logoLSSR - molecule cluster A1390EHD4, HCA10, HCA11EH-domain containing protein 4

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensEHD4_HUMANQ9H22354161175605892

Functions and Classifications

GOC:early endosome membrane, C:endoplasmic reticulum, C:nucleus, C:perinuclear region of cytoplasm, C:plasma membrane, C:recycling endosome membrane, F:ATP binding, F:calcium ion binding, F:GTP binding, F:GTPase activity, F:nucleic acid binding, P:cellular response to growth factor stimulus, P:endocytic recycling, P:GTP catabolic process, P:pinocytosis, P:positive regulation of peptidyl-tyrosine phosphorylation, P:protein homooligomerization, P:regulation of endocytosis
UniProtATP-binding, Calcium, Cell membrane, Complete proteome, Endosome, Membrane, Metal-binding, Nucleotide-binding, Phosphoprotein, Polymorphism, Reference proteome
PADBUK: unknown

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
0000004060000000

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
18501002mousekidneycortexPlasma Membranehealthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
15253431humanheartmitochondria healthy     Unique peptides: 2
21616181mousecornea  lumican knock-out   1.04 
17172703humanmultiplemitochondriaMitochondrialhealthy     detection: high confidence prediction (Mitopred)confidence %: 99
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 3
12724530humanHela cell extractlipid raftspH-resistant rafthealthy      
17436268mousekidneycortex diabetes     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
15378748mouselungbronchoalveolar lavage asthma (dex-sensitised and challenged)   0.6 
15326289humanurineexosomecytoplasm (endosomal trafficking) healthy     
18373357humanurinemicroparticles bladder cancer   3 
21127740humanurinewhole acute abdominal pain     Identified peptides: 47
18578523humanPC3 cancer cellsecretion       
23308193humanbladder cancer cell linecytosolic and nuclear fractionation bladder cancer   0.48 
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
20334419humanprostateprostate secretion healthy     
19056867humanurineexosome healthy     Identified peptides: 17

Compile date 12-23-2014© PADB initiative