PADB-logoLSSR - molecule cluster A1256UBBPolyubiquitin-B

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensUBB_HUMANP0CG4722925762191339

Functions and Classifications

GOC:cytosol, C:endocytic vesicle membrane, C:endosome membrane, C:nucleoplasm, C:plasma membrane, P:activation of MAPK activity, P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, P:apoptotic signaling pathway, P:cytokine-mediated signaling pathway, P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, P:DNA repair, P:endosomal transport, P:epidermal growth factor receptor signaling pathway, P:Fc-epsilon receptor signaling pathway, P:fibroblast growth factor receptor signaling pathway, P:G1/S transition of mitotic cell cycle, P:I-kappaB kinase/NF-kappaB signaling, P:innate immune response, P:ion transmembrane transport, P:JNK cascade, P:mRNA metabolic process, P:MyD88-dependent toll-like receptor signaling pathway, P:negative regulation of apoptotic process, P:negative regulation of epidermal growth factor receptor signaling pathway, P:negative regulation of transcription from RNA polymerase II promoter, P:negative regulation of transforming growth factor beta receptor signaling pathway, P:negative regulation of type I interferon production, P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:neurotrophin TRK receptor signaling pathway, P:Notch receptor processing, P:Notch signaling pathway, P:nucleotide-binding oligomerization domain containing signaling pathway, P:positive regulation of apoptotic process, P:positive regulation of I-kappaB kinase/NF-kappaB signaling, P:positive regulation of NF-kappaB transcription factor activity, P:positive regulation of transcription from RNA polymerase II promoter, P:positive regulation of type I interferon production, P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:protein polyubiquitination, P:regulation of transcription from RNA polymerase II promoter in response to hypoxia, P:T cell receptor signaling pathway, P:toll-like receptor 10 signaling pathway, P:toll-like receptor 2 signaling pathway, P:toll-like receptor 3 signaling pathway, P:toll-like receptor 4 signaling pathway, P:toll-like receptor 5 signaling pathway, P:toll-like receptor 9 signaling pathway, P:toll-like receptor TLR1:TLR2 signaling pathway, P:toll-like receptor TLR6:TLR2 signaling pathway, P:transcription initiation from RNA polymerase II promoter, P:transforming growth factor beta receptor signaling pathway, P:TRIF-dependent toll-like receptor signaling pathway, P:viral protein processing, P:virion assembly, P:apoptotic process, P:cellular membrane organization, P:egress of virus within host cell, P:G1 phase of mitotic cell cycle, P:I-kappaB kinase/NF-kappaB cascade, P:M/G1 transition of mitotic cell cycle, P:nerve growth factor receptor signaling pathway, P:positive regulation of I-kappaB kinase/NF-kappaB cascade, P:regulation of apoptotic process, P:S phase of mitotic cell cycle, P:Toll signaling pathway, P:toll-like receptor 1 signaling pathway, P:TRIF-dependent toll-like receptor signaling pathway", P:energy homeostasis, P:fat pad development, P:female gonad development, P:female meiosis I, P:hypothalamus gonadotrophin-releasing hormone neuron development, P:male meiosis I, P:seminiferous tubule development, P:ubiquitin homeostasis
UniProtComplete proteome, Cytoplasm, Direct protein sequencing, Isopeptide bond, Nucleus, Reference proteome, Repeat, Ubl conjugation
PADBSIG: signalling

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
10, 10, 10, 10, 10, 108, 8, 6, 8, 8, 88, 8, 11, 8, 8, 88, 8, 2, 8, 8, 82, 2, 0, 3, 2, 26, 6, 4, 7, 6, 60, 0, 0, 0, 0, 04, 4, 4, 3, 3, 44, 4, 0, 4, 4, 44, 4, 2, 4, 4, 49, 9, 11, 9, 9, 93, 3, 2, 3, 4, 313, 13, 17, 15, 13, 1321, 21, 29, 20, 21, 22

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
16948836humanurinewhole healthy     
18501002mousekidneycortexCytoplasmhealthy     
17723740humanurinewhole healthy     
16446289humanhairshaft healthy     
18361515humansalivaParotid;SMSL healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
15852343ratbrainPSD cerebral cortex (frontal) healthy     
15020595ratbrainPSD (forebrain) healthy     
21616181mousecornea  lumican knock-out   1.075 
14720225ratbrainPSD forebrain healthy      
14720225ratbrainPSD forebrain healthy      
16635246mousebrainPSD (forebrain) healthy      
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 7
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
19455133mousebrainPSD95-associated proteins healthy     Identified peptides: 2
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
12176931humanHela cell extractspliceosome healthy      
12724530humanHela cell extractlipid raftspH-resistant rafthealthy      
12724530humanHela cell extractlipid raftspH-resistant raft; detergent-resistant raft; Membrane proteinhealthy      
14633944humanintestinal epitheliaexosomecytoplasm (endosomal trafficking) healthy     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
15593129ratkidneyrenal cortex, basolateral membrane vesicles healthy     
15593129ratkidneyrenal cortex, brush border membrane vesicles healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
16691549ratliverGolgi healthy      
16691549ratliverGolgi healthy      
15951573humanlungbronchoalveolar lavage asthma     
15761959humanlungbronchoalveolar lavage Sarcoidosis; Idiopathic pulmonary fibrosis; Pulmonary fibrosis associated with systemic sclerosis     p-value: <0.01
18334958humantearwholecytoplasmhealthy      
15048996humanurinewholeintracellularhealthy     
15048996humanurinewholeintracellularhealthy     
17634209humanurinewhole type 2 diabetes with macro- or microalbuminuria (DM-NP)  strongly reduced  
17494094humanurinewhole healthy; tubular proteinuria (TP), X-linked form of renal Fanconi syndrome; Dent's disease, X-linked form of renal Fanconi syndrome; Lowe disease, X-linked form of renal Fanconi syndrome; autosomal dominant idiopathic form (ADIF) of renal Fanconi syndrome   0.33 
15140760humanurinewhole Dent's disease   <1 Identified peptides: 7
15326289humanurineexosomecytoplasm (endosomal trafficking) healthy     
17518487humanurinewholecytoplasm bladder cancer     
21538913humanurinewhole cancer (upper GI)     
UNPUBLISHED_1humanurinewhole healthy, cancer     
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
UNPUBLISHED_3humanPC3 cancer cellwhole        
20334419humanprostateprostate secretion healthy     

Compile date 12-23-2014© PADB initiative