PADB-logoLSSR - molecule cluster A0814DDX5, G17P1, HELRProbable RNA-dependent helicase p68

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensDDX5_HUMANP1784461469148180630

Functions and Classifications

GOC:catalytic step 2 spliceosome, C:nucleolus, F:androgen receptor binding, F:ATP binding, F:ATP-dependent RNA helicase activity, F:estrogen receptor binding, F:pre-mRNA binding, F:RNA helicase activity, F:transcription coactivator activity, P:ATP catabolic process, P:cell growth, P:circadian rhythm, P:in utero embryonic development, P:intrinsic apoptotic signaling pathway by p53 class mediator, P:mRNA splicing, via spliceosome, P:negative regulation of transcription from RNA polymerase II promoter, P:positive regulation of DNA damage response, signal transduction by p53 class mediator, P:positive regulation of intracellular estrogen receptor signaling pathway, P:positive regulation of transcription from RNA polymerase II promoter, P:regulation of alternative mRNA splicing, via spliceosome, P:regulation of androgen receptor signaling pathway, P:regulation of osteoblast differentiation, P:regulation of skeletal muscle cell differentiation, P:regulation of viral genome replication, P:transcription, DNA-templated, C:nucleus, F:ATP-dependent helicase activity, F:nucleic acid binding, F:transcription cofactor activity, P:regulation of RNA biosynthetic process, P:transcription, DNA-dependent", P:positive regulation of transcription, DNA-templated
UniProt3D-structure, Acetylation, ATP-binding, Complete proteome, Helicase, Hydrolase, Isopeptide bond, mRNA processing, mRNA splicing, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, RNA-binding, Spliceosome, Transcription, Transcription regulation, Ubl conjugation
PADBENZ: enzyme, enzymatic properties

Expression

ratios [in mouse]
cytosol/nucleusheart/brainkidney/brainliver/brain
0.04   

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
18501002mousekidneycortexNucleushealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 1
15020595ratbrainPSD (forebrain) healthy     
21616181mousecornea  lumican knock-out   0.93 
16635246mousebrainPSD (forebrain) healthy      
12176931humanHela cell extractspliceosome healthy      
12724530humanHela cell extractlipid raftsdetergent-resistant rafthealthy      
16381850humanHela cell extractnucleus healthy     theoretical Mr: 69618
15905145ratkidneyinner medullary collecting duct (IMCD) Isolation of AQP-2 containing intracellular vesicles     
16449382ratkidneyinner medullary collecting duct (IMCD) 3 day Vasopressin infusion to Brattleboro rat     
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
17711322humankidneyglomerulus healthy     
16615899mouseliverorganelleER/Golgi vesicles (ERGDV)|Recycling endosomes (RE/TGN)|Nucleushealthy     
23308193humanbladder cancer cell linecytosolic and nuclear fractionation bladder cancer   1 
UNPUBLISHED_3humanPC3 cancer cellwhole        
19056867humanurineexosome healthy     Identified peptides: 1

Compile date 12-23-2014© PADB initiative