PADB-logoLSSR - molecule cluster A0567GDI1, GDIL, OPHN2Rab GDP dissociation inhibitor alpha

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensGDIA_HUMANP3115044750583300104, 300849

Functions and Classifications

GOC:cytosol, C:midbody, C:neuron projection, C:protein complex, F:GTPase activator activity, F:Rab GDP-dissociation inhibitor activity, P:negative regulation of axonogenesis, P:negative regulation of protein targeting to membrane, P:positive regulation of GTPase activity, P:protein transport, P:Rab protein signal transduction, P:regulation of small GTPase mediated signal transduction, P:response to calcium ion, P:regulation of catalytic activity, F:GDP-dissociation inhibitor activity, P:small GTPase mediated signal transduction
UniProtComplete proteome, Cytoplasm, Direct protein sequencing, Disease mutation, Golgi apparatus, GTPase activation, Mental retardation, Reference proteome, Phosphoprotein
PADBDIS: disease

Expression

ratios [in mouse]
cytosol/nucleusheart/brainkidney/brainliver/brain
65   
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
23036230000509005

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
18501002mousekidneycortexCytoplasmhealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 9
18361515humansalivaParotid healthy     Identified peptides: 5
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   1.175 
16861337humanblooderythrocytecytoplasmichealthy     Identified peptides: 1
15447677ratbrainmGluR5 complex isolation healthy      
14720225ratbrainPSD forebrainpostsynaptichealthy     
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 21
19455133mousebrainPSD95-associated proteins healthy     Identified peptides: 5
15852343ratbrainPSD cerebral cortex (frontal) healthy     Sequence coverage: 40.66
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
16615899mouseliverorganelleCytosol (Cyto)healthy     
18373357humanurinemicroparticles bladder cancer   2 
21127740humanurinewhole acute abdominal pain     Identified peptides: 25
18578523humanPC3 cancer cellsecretion       
18578523humanPC3 cancer cellsecretion       
23308193humanbladder cancer cell linecytosolic and nuclear fractionation bladder cancer   1.51 
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
20334419humanprostateprostate secretion healthy     

Compile date 12-23-2014© PADB initiative