PADB-logoLSSR - molecule cluster A0539DOCK1Dedicator of cytokinesis protein 1

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensDOCK1_HUMANQ141851865215376601403

Functions and Classifications

GOC:cytosol, C:membrane, F:GTPase activator activity, F:guanyl-nucleotide exchange factor activity, P:apoptotic process, P:axon guidance, P:blood coagulation, P:cell migration, P:Fc-gamma receptor signaling pathway involved in phagocytosis, P:innate immune response, P:integrin-mediated signaling pathway, P:phagocytosis, engulfment, P:small GTPase mediated signal transduction, P:regulation of GTPase activity, P:small GTPase mediated signal transduction
UniProt3D-structure, Apoptosis, Complete proteome, Cytoplasm, Guanine-nucleotide releasing factor, Membrane, Phagocytosis, Phosphoprotein, Polymorphism, Reference proteome, SH3 domain, SH3-binding
PADBMOD: modulator, regulator

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
0000000000001000

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16684767humanbloodplasma severe trauma     Identified peptides: 1
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   1.1 
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 6
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
17474143mousekidneyperoxisomesPeroxisomal/Cytosolichealthy     
17474143mouseliverperoxisomesPeroxisomal/Cytosolichealthy     
20198343humanurinewhole cancer - weight stable     

Compile date 12-23-2014© PADB initiative