PADB-logoLSSR - molecule cluster A0454DSPDesmoplakin

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensDESP_HUMANP159242871331776125647, 605676, 607450, 607655, 609638, 612908

Functions and Classifications

GOC:basolateral plasma membrane, C:cornified envelope, C:desmosome, C:fascia adherens, C:intercalated disc, C:intermediate filament, C:mitochondrion, C:plasma membrane, F:protein binding, bridging, F:structural constituent of cytoskeleton, P:adherens junction organization, P:bundle of His cell to Purkinje myocyte communication, P:cell-cell adhesion, P:cellular component disassembly involved in execution phase of apoptosis, P:desmosome organization, P:intermediate filament organization, P:keratinocyte differentiation, P:peptide cross-linking, P:protein localization to adherens junction, P:regulation of heart rate by cardiac conduction, P:regulation of ventricular cardiac muscle cell action potential, P:ventricular compact myocardium morphogenesis, P:wound healing, C:basolateral plasma membrane, P:skin development, P:wound healing, C:cell junction, C:cytoskeleton
UniProt3D-structure, Alternative splicing, Cardiomyopathy, Cell junction, Coiled coil, Complete proteome, Cytoplasm, Cytoskeleton, Disease mutation, Epidermolysis bullosa, Lipoprotein, Palmoplantar keratoderma, Phosphoprotein, Polymorphism, Reference proteome, Repeat
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
0, 00, 00, 00, 033, 6410, 00, 05, 90, 00, 029, 024, 270, 00, 0

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
16901338humantearwhole healthy     
16446289humanhairshaft healthy     
18361515humansalivaParotid;SMSL healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
15020595ratbrainPSD (forebrain) healthy     
21616181mousecornea  lumican knock-out   0.895 
11279284mousebrainAMPA-receptor co-IP (forebrain) healthy      
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 4
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
16641100ratkidneyinner medullary collecting duct (IMCD) Phosphoproteome of IMCD     
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
17711322humankidneyglomerulus healthy     
16615899mouseliverorganelle healthy     
16615899mouseliverorganelle healthy     
16615899mouseliverorganelle healthy     
15951573humanlungbronchoalveolar lavage asthma     
18373357humanurinemicroparticles bladder cancer   0.4 
21127740humanurinewhole acute abdominal pain     Identified peptides: 43
UNPUBLISHED_1humanurinewhole healthy, cancer     
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
18553995humanprostatewhole prostate cancer      
19056867humanurineexosome healthy     Identified peptides: 10
19056867humanurineexosome healthy     Identified peptides: 4

Compile date 12-23-2014© PADB initiative