PADB-logoLSSR - molecule cluster A0340ATP1A1Sodium/potassium-transporting ATPase alpha-1 chain precursor

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensAT1A1_HUMANP050231023112896182310

Functions and Classifications

GOC:basolateral plasma membrane, C:caveola, C:endoplasmic reticulum, C:endosome, C:Golgi apparatus, C:melanosome, C:sodium:potassium-exchanging ATPase complex, C:T-tubule, F:ADP binding, F:ATP binding, F:chaperone binding, F:potassium ion binding, F:sodium ion binding, F:sodium:potassium-exchanging ATPase activity, P:ATP biosynthetic process, P:cellular response to mechanical stimulus, P:membrane hyperpolarization, P:negative regulation of glucocorticoid biosynthetic process, P:negative regulation of heart contraction, P:positive regulation of heart contraction, P:positive regulation of striated muscle contraction, P:potassium ion import, P:regulation of blood pressure, P:regulation of cardiac muscle cell contraction, P:regulation of sodium ion transport, P:regulation of the force of heart contraction, P:response to drug, C:integral component of membrane, F:cation-transporting ATPase activity, F:metal ion binding, F:monovalent inorganic cation transmembrane transporter activity, P:ATP catabolic process, P:ion transmembrane transport, P:sodium ion transmembrane transport, C:sarcolemma, F:4-nitrophenylphosphatase activity, "C:integral to membrane, F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, P:ATP biosynthetic process", P:cation transport", "C:membrane
UniProtAlternative splicing, ATP-binding, Cell membrane, Complete proteome, Direct protein sequencing, Hydrolase, Ion transport, Magnesium, Membrane, Metal-binding, Nucleotide-binding, Phosphoprotein, Polymorphism, Potassium, Potassium transport, Reference proteome, Sodium, Sodium transport, Sodium/potassium transport, Transmembrane, Transmembrane helix, Transport
PADBENZ: enzyme, enzymatic properties

Expression

ratios [in mouse]
cytosol/nucleusheart/brainkidney/brainliver/brain
0.41   
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
13121111160021520613

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
18501002mousekidneycortexPlasma Membranehealthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   0.935 
16861337humanblooderythrocyteintegral membrane proteinhealthy     Identified peptides: 10
10862698mousebrainNMDA-receptor co-IP, PDZ-affinity peptide (forebrain) healthy      
11279284mousebrainAMPA-receptor co-IP (forebrain) healthy      
16635246mousebrainPSD (forebrain) healthy      
15447677ratbrainmGluR5 complex isolation healthy      
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 37
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15852343ratbrainPSD cerebral cortex (frontal) healthy     Sequence coverage: 11.82
12724530humanHela cell extractlipid raftspH-resistant raft; detergent-resistant rafthealthy      
15905145ratkidneyinner medullary collecting duct (IMCD) Isolation of AQP-2 containing intracellular vesicles     
16449382ratkidneyinner medullary collecting duct (IMCD) 3 day Vasopressin infusion to Brattleboro rat   0.87 0.04 
16449382ratkidneyinner medullary collecting duct (IMCD) IMCD vs. non-IMCD protein amounts   1.35 0.05 
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
15593129ratkidneyrenal cortex, brush border membrane vesicles healthy     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
17768142mousekidneyperoxisomal membraneplasma membranehealthy     
17768142mousekidneyperoxisomal membraneplasma membranehealthy     
15593129ratkidneyrenal cortex, basolateral membrane vesicles healthy     
15593129ratkidneyrenal cortex, basolateral membrane vesicles healthy     
15593129ratkidneyrenal cortex, brush border membrane vesicles healthy     
15593129ratkidneyrenal cortex, basolateral membrane vesicles healthy     
15593129ratkidneyrenal cortex, brush border membrane vesicles healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
15047867ratliverGolgi healthy     Sequence coverage: 8.6
16691549ratliverGolgi healthy      
16691549ratliverGolgi healthy      
16615899mouseliverorganelleNucleushealthy     
15684408mouseplasma membranebrain cortex and hippocampus healthy     
18373357humanurinemicroparticles bladder cancer   0.6 
21127740humanurinewhole acute abdominal pain     Identified peptides: 187
18578523humanPC3 cancer cellsecretion       
18578523humanPC3 cancer cellsecretion       
23308193humanbladder cancer cell linecytosolic and nuclear fractionation bladder cancer   1.05 
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
UNPUBLISHED_2humanliverwhole, fetal healthy     
18553995humanprostatewhole prostate cancer     Identified peptides: 8

Compile date 12-23-2014© PADB initiative