PADB-logoLSSR - molecule cluster A0305PRKAR2A, PKR2, PRKAR2cAMP-dependent protein kinase type II-alpha regulatory chain

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensKAP2_HUMANP1386140345387176910

Functions and Classifications

GOC:AMP-activated protein kinase complex, C:cAMP-dependent protein kinase complex, C:centrosome, C:cytosol, C:plasma membrane, F:cAMP binding, F:cAMP-dependent protein kinase inhibitor activity, F:cAMP-dependent protein kinase regulator activity, F:ubiquitin protein ligase binding, P:activation of phospholipase C activity, P:activation of protein kinase A activity, P:blood coagulation, P:cellular response to glucagon stimulus, P:energy reserve metabolic process, P:epidermal growth factor receptor signaling pathway, P:fibroblast growth factor receptor signaling pathway, P:innate immune response, P:intracellular signal transduction, P:negative regulation of cAMP-dependent protein kinase activity, P:neurotrophin TRK receptor signaling pathway, P:regulation of insulin secretion, P:small molecule metabolic process, P:transmembrane transport, P:water transport, P:regulation of protein kinase activity, F:kinase activity, C:perinuclear region of cytoplasm, C:T-tubule, P:nerve growth factor receptor signaling pathway, P:protein heterooligomerization, P:signal transduction
UniProt3D-structure, Acetylation, cAMP, cAMP-binding, Cell membrane, Complete proteome, Cytoplasm, Membrane, Nucleotide-binding, Phosphoprotein, Reference proteome, Repeat, Kinase, Transferase
PADBENZ: enzyme, enzymatic properties

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
0000000000001000

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
18501002mousekidneycortexCytoplasmhealthy     
16709260humansemenplasma healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   1 
16861337humanblooderythrocytecytoplasmichealthy     
1512224ratbrainPSD forebrain healthy      
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 8
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
16641100ratkidneyinner medullary collecting duct (IMCD) Phosphoproteome of IMCD     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
16691549ratliverGolgi healthy      
16615899mouseliverorganelleCytosol (Cyto)healthy     
15951573humanlungbronchoalveolar lavage asthma     
15684408mouseplasma membranebrain cortex and hippocampus healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
18553995humanprostatewhole prostate cancer     Identified peptides: 4
20334419humanprostateprostate secretion healthy     
19056867humanurineexosome healthy     Identified peptides: 1

Compile date 12-23-2014© PADB initiative