PADB-logoLSSR - molecule cluster A0261PFKM, PFKX6-phosphofructokinase, muscle type

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensK6PF_HUMANP0823777985051232800, 610681, 171850

Functions and Classifications

GOC:6-phosphofructokinase complex, C:apical plasma membrane, F:6-phosphofructokinase activity, F:ATP binding, F:fructose binding, F:metal ion binding, P:fructose 6-phosphate metabolic process, P:glucose homeostasis, P:glycolysis, P:muscle cell cellular homeostasis, P:positive regulation of insulin secretion, P:protein oligomerization, P:small molecule metabolic process, P:carbohydrate phosphorylation, "C:6-phosphofructokinase complex, F:AMP binding, F:fructose-6-phosphate binding, P:fructose 1,6-bisphosphate metabolic process, P:muscle cell homeostasis, P:protein homotetramerization, P:small molecule metabolic process", P:protein homotetramerization"
UniProtAcetylation, Allosteric enzyme, Alternative splicing, ATP-binding, Complete proteome, Disease mutation, Glycogen storage disease, Glycolysis, Glycoprotein, Kinase, Magnesium, Metal-binding, Nucleotide-binding, Phosphoprotein, Reference proteome, Repeat, Transferase
PADBENZ: enzyme, enzymatic properties

Expression

ratios [in mouse]
cytosol/nucleusheart/brainkidney/brainliver/brain
4.3   
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
412182300043000000

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
15253431humanheartmitochondria healthy     Unique peptides: 3
15253431humanheartmitochondria healthy     Unique peptides: 1
21616181mousecornea  lumican knock-out   1.06 
16861337humanblooderythrocyteglycolisis, cytoplasmichealthy     Identified peptides: 3
16635246mousebrainPSD (forebrain) healthy      
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 15
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
19455133mousebrainPSD95-associated proteins healthy     Identified peptides: 4
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
16047384ratbrainPSD pre- and postsynapse (cortex)pre- and postsynaptichealthy     Sequence coverage: 5.8
15852343ratbrainPSD cerebral cortex (frontal) healthy     Sequence coverage: 1.39
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
16615899mouseliverorganelleCytosol (Cyto)healthy     
UNPUBLISHED_1humanurinewhole cancer     
23308193humanbladder cancer cell linecytosolic and nuclear fractionation bladder cancer   1.51 
23376485humanurinepodocyte healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     

Compile date 12-23-2014© PADB initiative