PADB-logoLSSR - molecule cluster A0117NSFVesicle-fusing ATPase

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensNSF_HUMANP4645974482654601633

Functions and Classifications

GOC:cytosol, C:lysosomal membrane, C:plasma membrane, F:ATP binding, F:ATPase activity, coupled, F:metal ion binding, F:protein complex binding, P:ATP catabolic process, P:exocytosis, P:plasma membrane fusion, P:positive regulation of receptor recycling, P:potassium ion transport, P:protein transport, P:synaptic transmission, F:nucleoside-triphosphatase activity, P:metabolic process, "C:lysosomal membrane, P:potassium ion transport", "C:cytoplasm, C:dendritic shaft, C:Golgi stack, P:regulation of exocytosis, "C:dendritic shaft, P:vesicle-mediated transport"
UniProtATP-binding, Complete proteome, Cytoplasm, Hydrolase, Magnesium, Metal-binding, Nucleotide-binding, Phosphoprotein, Polymorphism, Protein transport, Reference proteome, Repeat, Transport
PADBENZ: enzyme, enzymatic properties

Expression

ratios [in rat]
cytosol/nucleusheart/brainkidney/brainliver/brain
 0.780.810.85
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
132032310000300100

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
18501002mousekidneycortexCytoplasmhealthy     
16684767humanbloodplasma severe trauma     Identified peptides: 1
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
16507876ratbrainPSD (forebrain and cerebellum) healthy     Identified peptides: 2
15020595ratbrainPSD (forebrain) healthy     
21616181mousecornea  lumican knock-out   1.005 
16861337humanblooderythrocytecytoplasmichealthy     
1629737bovinebrainPSD cerebral cortex healthy      
10862698mousebrainNMDA-receptor co-IP, PDZ-affinity peptide (forebrain) healthy      
14720225ratbrainPSD forebrain healthy      
16635246mousebrainPSD (forebrain) healthy      
14532281ratbrainPSD forebrain healthy     
15447677ratbrainmGluR5 complex isolation healthy      
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 41
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
19455133mousebrainPSD95-associated proteins healthy     Identified peptides: 16
19455133mousebrainPSD95-associated proteins healthy     Identified peptides: 24
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
15169875rat; mousebrainPSD (whole brain) healthy     
16047384ratbrainPSD pre- and postsynapse (cortex)pre- and postsynaptichealthy     Sequence coverage: 16.8
16332460ratbrainPSD (hippocampus) healthy     Identified peptides: 13
16928776ratbrain;heart;kidney;livermitochondria healthy      
18536710drosohila (fruit fly)headPDZ-affinity peptide healthy     Identified peptides: 29
12724530humanHela cell extractlipid raftspH-resistant rafthealthy      
17711322humankidneyglomerulus healthy     
16691549ratliverGolgi healthy      
16615899mouseliverorganelleER/Golgi vesicles (ERGDV)|Early endosomes (EE)healthy     
15951573humanlungbronchoalveolar lavage asthma     
15684408mouseplasma membranebrain cortex and hippocampus healthy     
23308193humanbladder cancer cell linecytosolic and nuclear fractionation bladder cancer   1.83 
23376485humanurinepodocyte healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainfrontal cortex healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_2sheepbrainhippocampus healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
18553995humanprostatewhole prostate cancer     Identified peptides: 6
20334419humanprostateprostate secretion healthy     

Compile date 12-23-2014© PADB initiative