PADB-logoLSSR - molecule cluster A0050GNAI3Guanine nucleotide-binding protein G(k), alpha subunit

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensGNAI3_HUMANP0875435440532139370, 602483

Functions and Classifications

GOC:centrosome, C:Golgi apparatus, C:heterotrimeric G-protein complex, C:lysosomal membrane, C:membrane raft, C:midbody, C:zymogen granule, F:G-protein beta/gamma-subunit complex binding, F:G-protein coupled serotonin receptor binding, F:GTP binding, F:GTPase activity, F:metal ion binding, F:signal transducer activity, P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, P:cell cycle, P:cell division, P:negative regulation of adenylate cyclase activity, P:platelet activation, P:synaptic transmission, P:transport, P:vesicle fusion, C:plasma membrane, P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway, C:cytoplasm, P:negative regulation of synaptic transmission, P:G-protein coupled receptor signaling pathway
UniProt3D-structure, ADP-ribosylation, Cell cycle, Cell division, Cell membrane, Complete proteome, Cytoplasm, Cytoskeleton, Disease mutation, GTP-binding, Lipoprotein, Magnesium, Membrane, Metal-binding, Myristate, Nucleotide-binding, Palmitate, Reference proteome, Transducer
PADBMOD: modulator, regulator

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
3310000007033367

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
18501002mousekidneycortexCytoplasmhealthy     
16709260humansemenplasma healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   0.895 
16861337humanblooderythrocyteinner surface of plasma membranehealthy     Identified peptides: 23
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 13
15852343ratbrainPSD cerebral cortex (frontal) healthy     Sequence coverage: 3.06
12724530humanHela cell extractlipid raftspH-resistant raft; detergent-resistant raft; Raft proteinhealthy      
15905145ratkidneyinner medullary collecting duct (IMCD) Isolation of AQP-2 containing intracellular vesicles     
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
15593129ratkidneyrenal cortex, basolateral membrane vesicles healthy     
17711322humankidneyglomerulus healthy     
15593129ratkidneyrenal cortex, brush border membrane vesicles healthy     
16691549ratliverGolgi healthy      
15684408mouseplasma membranebrain cortex and hippocampus healthy     
15326289humanurineexosomeplasma membrane (peripheral)healthy     
18373357humanurinemicroparticles bladder cancer   1.5 
21127740humanurinewhole acute abdominal pain     Identified peptides: 132
19056867humanurineexosome healthy     Identified peptides: 8

Compile date 12-23-2014© PADB initiative