PADB-logoLSSR - molecule cluster A0044GNA11, GA11Guanine nucleotide-binding protein G(Y), alpha subunit 11

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensGNA11_HUMANP2999235942123139313, 145981, 615361

Functions and Classifications

GOC:heterotrimeric G-protein complex, C:lysosomal membrane, F:G-protein beta/gamma-subunit complex binding, F:G-protein coupled receptor binding, F:GTP binding, F:GTPase activity, F:metal ion binding, F:signal transducer activity, P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway, P:developmental pigmentation, P:heart development, P:phospholipase C-activating dopamine receptor signaling pathway, P:platelet activation, P:regulation of action potential, P:regulation of melanocyte differentiation, P:skeletal system development, C:cytoplasm, P:protein ADP-ribosylation, C:protein complex, P:G-protein coupled receptor signaling pathway
UniProtADP-ribosylation, Cell membrane, Complete proteome, Direct protein sequencing, Disease mutation, GTP-binding, Lipoprotein, Magnesium, Membrane, Metal-binding, Nucleotide-binding, Palmitate, Reference proteome, Transducer
PADBRIB: ribosome

Expression

percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
000000005045201020

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
16948836humanurinewhole healthy     
16948836humanurinewhole healthy     
18501002mousekidneycortexPlasma Membranehealthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   0.97 
21170055humanbrainPSD (neocortex) Glial neoplasm/Lesional epilepsy/Colloid cyst     Unique peptides: 3
12724530humanHela cell extractlipid raftspH-resistant raft; detergent-resistant raft; Raft proteinhealthy      
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
15593129ratkidneyrenal cortex, basolateral membrane vesicles healthy     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
15593129ratkidneyrenal cortex, brush border membrane vesicles healthy     
17711322humankidneyglomerulus healthy     
16615899mouseliverorganelleEndoplasmic reticulum (ER)|ER/Golgi vesicles (ERGDV)healthy     
15684408mouseplasma membranebrain cortex and hippocampus healthy     
15326289humanurineexosomeplasma membrane (peripheral)healthy     
18373357humanurinemicroparticles bladder cancer   0.4 
18373357humanurinemicroparticles bladder cancer   3 
21127740humanurinewhole acute abdominal pain     Identified peptides: 40
23376485humanurinepodocyte healthy     
23376485humanurinepodocyte healthy     
19056867humanurineexosome healthy     Identified peptides: 7

Compile date 12-23-2014© PADB initiative