cvd-logocvd - Study ID Exp27234505

PubMed ID27234505
AuthorsCheow ES(1), Cheng WC(2), Lee CN(3), de Kleijn D(4), Sorokin V(5), Sze SK(6).
TitlePlasma-derived Extracellular Vesicles Contain Predictive Biomarkers and Potential Therapeutic Targets for Myocardial Ischemic (MI) Injury.
JournalMol Cell Proteomics. 2016 Aug;15(8):2628-40.
AbstractMyocardial infarction (MI) triggers a potent inflammatory response via the release of circulatory mediators, including extracellular vesicles (EVs) by damaged cardiac cells, necessary for myocardial healing. Timely repression of inflammatory response are critical to prevent and minimize cardiac tissue injuries, nonetheless, progression in this aspect remains challenging. The ability of EVs to trigger a functional response upon delivery of carried bioactive cargos, have made them clinically attractive diagnostic biomarkers and vectors for therapeutic interventions. Using label-free quantitative proteomics approach, we compared the protein cargo of plasma EVs between patients with MI and from patients with stable angina (NMI). We report, for the first time, the proteomics profiling on 252 EV proteins that were modulated with >1.2-fold after MI. We identified six up-regulated biomarkers with potential for clinical applications; these reflected post-infarct pathways of complement activation (Complement C1q subcomponent subunit A (C1QA), 3.23-fold change, p = 0.012; Complement C5 (C5), 1.27-fold change, p = 0.087), lipoprotein metabolism (Apoliporotein D (APOD), 1.86-fold change, p = 0.033; Apolipoprotein C-III (APOCC3), 2.63-fold change, p = 0.029) and platelet activation (Platelet glycoprotein Ib alpha chain (GP1BA), 9.18-fold change, p < 0.0001; Platelet basic protein (PPBP), 4.72-fold change, p = 0.027). The data have been deposited to the ProteomeXchange with identifier PXD002950. This novel biomarker panel was validated in 43 patients using antibody-based assays (C1QA (p = 0.005); C5 (p = 0.0047), APOD (p = 0.0267); APOC3 (p = 0.0064); GP1BA (p = 0.0031); PPBP (p = 0.0465)). We further present that EV-derived fibrinogen components were paradoxically down-regulated in MI, suggesting that a compensatory mechanism may suppress post-infarct coagulation pathways, indicating potential for therapeutic targeting of this mechanism in MI. Taken together, these data demonstrated that plasma EVs contain novel diagnostic biomarkers and therapeutic targets that can be further developed for clinical use to benefit patients with coronary artery diseases (CADs).

Sample characteristics

SpeciesTissue / SourceCompartmentDiseaseNDetection methodSample
Homo sapiensbloodplasmaMI35LC-MS/MSDem27234505a, Dem27234505b

Sample description and preparation

N (case)15
N (control)20
Disease (case)Myocardial Ischemic Injury
Disease (control)stable angina (NMI)
Preparation specific methodlabel-free
Digestin-solution digestion, Trypsin
Storage condition-80C

Sample analysis

Software analysis toolThermo Scientific Proteome Discoverer
Software thresholdP<0.05, fold change>1.2

Molecule list

Molecule IDextExternal IDGeneNameSource accRegulation (case/control)Scores
A3857XKRT86_HUMANKRTHB6, KRT86, GHHKB6Keratin, type II cuticular HB6U3KPR1ratio: 0.003
BA526XNEIL3_HUMANNEIL3Endonuclease 8-like 3Q8TAT5ratio: 0.021
A096BXTDRD1_HUMANTDRD1Tudor domain containing protein 1Q9BXT4-4ratio: 0.022
A0625XMAP1B_HUMANMAP1BMicrotubule-associated protein 1BD6RA40ratio: 0.032
A123BXTNR6A_HUMANTNRC6A, TNRC6, GW1Trinucleotide repeat-containing gene 6A proteinQ8NDV7-6ratio: 0.036
A1470XTSP1_HUMANTHBS1, TSP, TSP1Thrombospondin 1 precursorP07996ratio: 0.078
A596CXTETN_HUMANCLEC3B, TNATetranectin precursorE9PHK0ratio: 0.086
A6723XHGFA_HUMANHGFACHepatocyte growth factor activator precursorQ04756ratio: 0.093
A0668XRUVB1_HUMANRUVBL1, INO80H, NMP238RuvB-like 1Q9Y265-2ratio: 0.119
A661BXTM198_HUMANTMEM198Transmembrane protein 198C9JXI5ratio: 0.139
A4549XACTBL_HUMANACTBL2Beta-actin-like protein 2Q562R1ratio: 0.141
A9829XCD5L_HUMANCD5L, API6, UNQ203/PRO229CD5 antigen-like precursorO43866ratio: 0.148
A5356XHORN_HUMANHRNR, S100A18HornerinQ86YZ3ratio: 0.172
A9713XFCGBP_HUMANFCGBPIgG Fc binding proteinQ9Y6R7ratio: 0.176
A4548XACTB_HUMANACTB, PS1TP5BP1Actin, cytoplasmic 1P60709ratio: 0.179
A3477XKCNQ2_HUMANKCNQ2, UNQ6166Potassium voltage-gated channel subfamily KQT member 2O43526-4ratio: 0.180
A8954XPROP_HUMANCFP, PFCComplement factor ProperdinP27918ratio: 0.183
A4566XALS_HUMANIGFALS, ALSInsulin-like growth factor binding protein complex acid labile chain precursorP35858ratio: 0.202
A6682XHABP2_HUMANHABP2, HGFAL, PHBPHGF activator like proteinB7Z8Q5ratio: 0.206
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP06310ratio: 0.227
BA890XNR4A3_HUMANNR4A3, CHN, CSMFNuclear hormone receptor NOR-1Q92570ratio: 0.228
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP01616ratio: 0.230
A3852XK22E_HUMANKRT2, KRT2A, KRT2EKeratin, type II cytoskeletal 2 epidermalP35908ratio: 0.237
A3849XK2C1_HUMANKRT1, KRTAKeratin, type II cytoskeletal 1P04264ratio: 0.241
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP01594ratio: 0.244
A1632XLCAT_HUMANLCATPhosphatidylcholine-sterol acyltransferase precursorJ3QKT0ratio: 0.260
A8381XAACT_HUMANSERPINA3, AACT, GIG24Alpha-1-antichymotrypsin precursorP01011ratio: 0.265
BD974XRNF6_HUMANRNF6, SPG2Ring finger protein 6Q9Y252ratio: 0.273
A504CXSHBG_HUMANSHBGSex hormone-binding globulin precursorI3L145ratio: 0.275
A8414XHEP2_HUMANSERPIND1, HCF2Serpin peptidase inhibitor, clade D (heparin cofactor), member 1P05546ratio: 0.276
A1467XFIBA_HUMANFGAFibrinogen alpha/alpha-E chain precursorP02671-2ratio: 0.278
A4876XK2C1B_HUMANKRT77, KRT1BKeratin 77Q7Z794ratio: 0.283
A4767XDYH5_HUMANDNAH5, DNAHC5, HL1Ciliary dynein heavy chain 5Q8TE73ratio: 0.286
A5077XPGS1_HUMANBGN, SLRR1ABiglycan precursorA6NLG9ratio: 0.288
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP01617ratio: 0.295
A5947XBTD_HUMANBTDBiotinidase precursorC9JSN9ratio: 0.298
A3824XK1C10_HUMANKRT10, KPPKeratin, type I cytoskeletal 10P13645ratio: 0.302
A3829XK1C9_HUMANKRT9Keratin, type I cytoskeletal 9P35527ratio: 0.303
A1669XK2C5_HUMANKRT5Keratin, type II cytoskeletal 5P13647ratio: 0.323
A1669XK2C5_HUMANKRT5Keratin, type II cytoskeletal 5P02538ratio: 0.323
A4551XACTC_HUMANACTC1, ACTCActin, alpha cardiac muscle 1P68032ratio: 0.334
A1601XC1S_HUMANC1SComplement C1s component precursorP09871ratio: 0.344
A8272XIGJ_HUMANIGJ, IGCJImmunoglobulin J chainP01591ratio: 0.347
A2264XFCN2_HUMANFCN2, FCNLFicolin 2 precursorQ15485ratio: 0.361
A1605XMASP1_HUMANMASP1, CRARF, CRARF1Complement factor MASP-3P48740-4ratio: 0.369
A8364XLV605_HUMANIGL, IGLV3-22, V2-15Ig lambda chainP01717ratio: 0.374
A1579XK1C14_HUMANK14, KRT14Keratin, type I cytoskeletal 14P02533ratio: 0.375
A1606XMASP2_HUMANMASP2, MASP-2Mannan-binding lectin serine protease 2O00187ratio: 0.378
A053CXKI20B_HUMANKIF20B, KRMP1, MPHOSPH1Kinesin-like protein KIF20BQ96Q89-4ratio: 0.390
A816BXAPOF_HUMANAPOFApolipoprotein F precursorF5GXS5ratio: 0.401
A504AXH2B1K_HUMANHIST1H2BC, HIST1H2BK, H2BFTHistone H2B KO60814ratio: 0.406
A810BXAPOA4_HUMANAPOA4, ApoA-IV, APOA-IVApolipoprotein A-IV precursorP06727ratio: 0.407
A7498XHELZ2_HUMANHELZ2, PRIC285, PDIP1betaPeroxisomal proliferator-activated receptor A-interacting complex 285 kDa proteinQ9BYK8-2ratio: 0.428
A8806XGEM_HUMANGEM, KIRGTP-binding protein GEMP06396ratio: 0.443
A1586XTRY1_HUMANPRSS1, TRP1, TRY1Protease serine 1P07477ratio: 0.459
A3860XKRT82_HUMANKRT82, KRTHB2, HB2Keratin type II cuticular HB2Q9NSB4ratio: 0.466
A812BXAPOC1_HUMANAPOC1, APOC1BApolipoprotein C-I precursorK7ERI9ratio: 0.467
A1038XIMA3_HUMANKPNA4, QIP1Importin alpha-4 subunitO00629ratio: 0.470
A809BXAPOA2_HUMANAPOA2Apolipoprotein A-II precursorP02652ratio: 0.473
B7787XINT10_HUMANINTS10Integrator complex subunit 10Q9NVR2ratio: 0.477
A9571XRL37A_HUMANRPL37A60S ribosomal protein L37AM0R2L6ratio: 0.480
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP01593ratio: 0.482
A1472XITB3_HUMANITGB3, GP3A, GPIIIAIntegrin beta-3 precursorI3L4X8ratio: 0.495
A1624XCO7_HUMANC7Complement component C7 precursorP10643ratio: 0.497
A0204XFLNA_HUMANFLNA, FLN, FLN1Filamin AQ5HY54ratio: 0.504
A6355XDOPO_HUMANDBHDopamine beta-monooxygenase precursorP09172ratio: 0.504
A498CXSEPP1_HUMANSEPP1, SELPSelenoprotein P precursorD6REX5ratio: 0.508
A1675XFBLN1_HUMANFBLN1, PP213Fibulin-1 precursorP23142ratio: 0.514
A5626XA1AG2_HUMANORM2, AGP2, AGP-BAlpha-1-acid glycoprotein 2 precursorP19652ratio: 0.520
A2266XFCN3_HUMANUNQ172, FCN3, FCNHFicolin 3 precursorO75636ratio: 0.522
A1493XFIBB_HUMANFGBFibrinogen beta chain precursorP02675ratio: 0.529
A643CXTRFE_HUMANTF, PRO1400Serotransferrin precursorP02787ratio: 0.533
A1611XHRG_HUMANHRGHistidine-rich glycoprotein precursorP04196ratio: 0.565
A8683XATRN_HUMANATRN, MGCAAttractin precursorO75882-3ratio: 0.568
A3748XK1C16_HUMANKRT16, KRT16AKeratin, type I cytoskeletal 16P08779ratio: 0.574
A5319XECM1_HUMANECM1Extracellular matrix protein 1 precursorQ16610ratio: 0.579
A8703XCASPC_HUMANCASP12, UNQ9415/PRO34398, CASP12P1Inactive Caspase-12Q6UXS9-3ratio: 0.579
A1737XFHR1_HUMANCFHL1P, H 36-2, CFHR1Complement factor H-related protein 1 precursorQ03591ratio: 0.588
A0787XFKBP4_HUMANFKBP4, FKBP52FK506-binding protein 4H0YFG2ratio: 0.589
A3500XKGP2_HUMANPRKG2, PRKGR2cGMP-dependent protein kinase 2E7EPE6ratio: 0.589
A8720XCO4A_HUMANC4A, CO4, CPAMD2Complement C4 precursorP0C0L4ratio: 0.590
A8721XCO4B_HUMANC4B, C4B12, C4B-1Complement C4-B precursorP0C0L5ratio: 0.590
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP01610ratio: 0.609
A1539XKNG1_HUMANKNG1, BDK, KNGKininogen-1P01042ratio: 0.619
A1541XKLKB1_HUMANKLKB1, KLK3Plasma kallikrein precursorP03952ratio: 0.625
A491AXH2AV_HUMANH2AFV, H2AVHistone H2A.F/Z variantQ71UI9-2ratio: 0.629
A1276XCLUS_HUMANCLU, APOJ, CLIClusterin precursorP10909-4ratio: 0.638
A2381XARHGH_HUMANARHGEF17, TEM4RHO guanine nucleotide exchange factor 17Q96PE2ratio: 0.643
A1494XFIBG_HUMANFGG, PRO2061Fibrinogen gamma chain precursorP02679-2ratio: 0.646
A9453XPLXD1_HUMANPLXND1Plexin-D1Q9Y4D7-2ratio: 0.652
A6605XGLPK_HUMANGKGlycerol kinaseH7C2A0ratio: 0.654
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP01605ratio: 0.660
A521BXLRRN4_HUMANLRRN4Leucine-rich repeat neuronal protein 4Q8WUT4ratio: 0.661
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP01624ratio: 0.662
A735CXA1BG_HUMANA1BGAlpha-1B-glycoprotein precursorP04217ratio: 0.665
A0119XCLH1_HUMANCLTC, CLH17, CLTCL2Clathrin heavy chain 1J3QL20ratio: 0.665
A1545XC4BPB_HUMANC4BPBC4b-binding protein beta chain precursorP20851-2ratio: 0.672
A8384XANT3_HUMANAT3, SERPINC1, PRO0309Antithrombin-III precursorP01008ratio: 0.673
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP04434ratio: 0.674
A8783XFETUA_HUMANAHSG, FETUA, PRO2743Alpha-2-HS-glycoprotein precursorP02765ratio: 0.697
B1716XC1QT6_HUMANC1QTNF6, CTRP6, UNQ581/PRO1151Complement-C1Q tumor necrosis factor-related protein 6 precursorF8WC87ratio: 0.713
A817BXAPOL1_HUMANAPOL1, APOLApolipoprotein L1 precursorO14791-3ratio: 0.714
A3825XK1C24_HUMANKRT24, KA24Keratin, type I cytoskeletal 24Q2M2I5ratio: 0.725
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP04207ratio: 0.738
A1597XSAMP_HUMANAPCS, PTX2Serum amyloid P-component precursorP02743ratio: 0.746
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP01621ratio: 0.748
A1939XHV102_HUMANIGH, VH1, IGHG1Immunoglobulin G1 Fab heavy chain variable regionP01857ratio: 0.750
A8274XIGLL1_HUMANIGLL1, IGL1, IGLJ14.1Immunoglobulin lambda-like polypeptide 1 precursorP15814ratio: 0.754
A8378XA2AP_HUMANSERPINF2, AAP, PLIAlpha-2-antiplasmin precursorP08697ratio: 0.758
A6798XINPP_HUMANINPP1Inositol polyphosphate 1-phosphataseC9J128ratio: 0.758
A219DXCS068_HUMAN Uncharacterized protein C19ORF68Q86XI8ratio: 0.760
A9149XVTDB_HUMANGCVitamin D-binding protein precursorP02774ratio: 0.763
A339BXSMCO1_HUMANSMCO1Uncharacterized protein C3ORF43Q147U7ratio: 0.764
A8363XIGHM_HUMANIGHM, IgIg mu chain CP01871ratio: 0.764
A195AXZA2G_HUMANAZGP1, ZAG, ZNGP1Zinc-alpha-2-glycoprotein precursorP25311ratio: 0.770
A1594XC4BPA_HUMANC4BPA, C4BPC4b-binding protein alpha chain precursorP04003ratio: 0.773
A1602XCFAB_HUMANCFB, BF, BFDComplement factor B precursorB4E1Z4ratio: 0.774
A8243XHV312_HUMANIGH, HuVH8B VH, scFvIg heavy chain V-III regionP01762ratio: 0.779
A8243XHV312_HUMANIGH, HuVH8B VH, scFvIg heavy chain V-III regionP01766ratio: 0.788
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP01612ratio: 0.791
A8434XITIH4_HUMANITIH4, IHRP, ITIHL1Inter-alpha-trypsin inhibitor heavy chain H4 precursorQ14624ratio: 0.794
A021CXHEMO_HUMANHPXHemopexin precursorP02790ratio: 0.798
A768CXKAD9_HUMANAK9, AKD1, AKD2Adenylate kinase domain containing 1Q5TCS8-6ratio: 0.814
A6447XERN1_HUMANERN1, IRE1Serine/threonine-protein kinase/endoribonuclease IRE1 precursorO75460ratio: 0.826
A1631XHPT_HUMANHPHaptoglobin precursorP00738ratio: 0.826
A7457XPON1_HUMANPON1, PONParaoxonase 1P27169ratio: 0.829
A8369XA1AT_HUMANA1A, SERPINA1, AATAlpha-1-antitrypsin precursorP01009ratio: 0.829
A8818XGPIX_HUMANGP9Platelet glycoprotein IX precursorP14770ratio: 1.225
A8729XCPN2_HUMANCPN2, ACBPCarboxypeptidase N subunit 2 precursorP22792ratio: 1.230
A1714XAPOB_HUMANAPOBApolipoprotein B-100 precursorP04114ratio: 1.242
A7381XPGRP2_HUMANPGLYRP2, PGLYRPL, PGRPLN-acetylmuramoyl-L-alanine amidase precursorQ96PD5ratio: 1.249
A1616XCO5_HUMANC5, CPAMD4Complement C5 precursorP01031ratio: 1.269
A1619XCFAI_HUMANCFI, IFComplement factor IG3XAM2ratio: 1.270
A8270XIGHG3_HUMANIGHG3Ig gamma-3 chainP01860ratio: 1.270
A940BXDOP1_HUMANDOPEY1Protein dopey-1F6U2K4ratio: 1.302
A4846XGP1BB_HUMANGP1BBPlatelet glycoprotein Ib beta chain precursorP13224ratio: 1.313
A8243XHV312_HUMANIGH, HuVH8B VH, scFvIg heavy chain V-III regionP01765ratio: 1.321
A1540XFA9_HUMANF9, FIX, F9p22Coagulation factor IX precursorP00740-2ratio: 1.335
A8271XIGHG4_HUMANIGHG4Ig gamma-4 chainP01861ratio: 1.351
A1424XIGHA2_HUMANIGHA2, IGH@Ig alpha-2 chainP01877ratio: 1.386
A589AXIF5A1_HUMANEIF5AEukaryotic translation initiation factor 5AI3L397ratio: 1.386
A6000XCBPB2_HUMANCPB2, PCPBCarboxypeptidase B2Q96IY4-2ratio: 1.395
A9319XGP115_HUMANGPR115, PGR18G-protein coupled receptor 115Q8IZF3ratio: 1.395
A1438XITA2B_HUMANITGA2B, GP2B, ITGABIntegrin alpha-IIb precursorP08514ratio: 1.414
A1613XCO2_HUMANC2Complement C2 precursorH0Y3H6ratio: 1.419
A1009XCDC5L_HUMANCDC5L, PCDC5RP, HSCDC5Cell division cycle 5-like proteinQ99459ratio: 1.421
A4331XHS12B_HUMANHSPA12BHeat shock 70 kDa protein 12BB4DLR4ratio: 1.423
A8432XITIH2_HUMANITIH2, IGHEP2Inter-alpha-trypsin inhibitor heavy chain H2 precursorQ5T985ratio: 1.431
A1599XCFAH_HUMANCFH, HF, HF1Complement factor H precursorP08603ratio: 1.436
A5589XSAA1_HUMANSAA1Serum amyloid A proteinP0DJI8ratio: 1.444
A470AXH12_HUMANHIST1H1C, H1F2Histone H1.2P16403ratio: 1.445
A1707XC1QB_HUMANC1QBComplement C1q subcomponent, B chain precursorD6R934ratio: 1.461
A2341XACTN1_HUMANACTN1Alpha-actinin 1P12814-3ratio: 1.461
A8364XLV605_HUMANIGL, IGLV3-22, V2-15Ig lambda chainP04208ratio: 1.461
A1715XAPOA_HUMANAPOA, LPAApolipoprotein(A) precursorP08519ratio: 1.467
A8433XITIH3_HUMANITIH3Inter-alpha-trypsin inhibitor heavy chain H3 precursorQ06033-2ratio: 1.469
A8448XPEDF_HUMANSERPINF1, PEDF, PIG35Pigment epithelium-derived factor precursorP36955ratio: 1.477
A8383XAMBP_HUMANAMBP, ITIL, HCPAMBP protein precursorP02760ratio: 1.494
A8364XLV605_HUMANIGL, IGLV3-22, V2-15Ig lambda chainP01700ratio: 1.505
A5590XSAA2_HUMANSAA2, HuSAA1g, HUSAA1GSerum amyloid A-2 proteinP0DJI9ratio: 1.510
A8243XHV312_HUMANIGH, HuVH8B VH, scFvIg heavy chain V-III regionP01781ratio: 1.537
A1598XCO3_HUMANC3, CPAMD1Complement C3 precursorP01024ratio: 1.594
A1625XCO8A_HUMANC8AComplement component C8 alpha chain precursorP07357ratio: 1.596
A8243XHV312_HUMANIGH, HuVH8B VH, scFvIg heavy chain V-III regionP01767ratio: 1.596
A8364XLV605_HUMANIGL, IGLV3-22, V2-15Ig lambda chainP01714ratio: 1.608
B8325XKEAP1_HUMANKEAP1, INRF2, KLHL19Kelch-like ECH-associated protein 1K7EPZ3ratio: 1.608
A8275XIGLL5_HUMANIGLL5, IGLV3-21, IGLIg lambda chain variantB9A064ratio: 1.613
A1177XA2MG_HUMANA2M, CPAMD5, FWP007Alpha-2-macroglobulin precursorP01023ratio: 1.615
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP01625ratio: 1.623
A4941XLG3BP_HUMANLGALS3BP, M2BPGalectin-3-binding protein precursorQ08380ratio: 1.676
A8269XIGHG2_HUMANIGHG2Ig gamma-2P01859ratio: 1.693
A1628XCO9_HUMANC9Complement component C9 precursorP02748ratio: 1.701
A1742XHBB_HUMANHBB, beta-globinHemoglobin beta chainP68871ratio: 1.741
A8243XHV312_HUMANIGH, HuVH8B VH, scFvIg heavy chain V-III regionP01763ratio: 1.794
A8364XLV605_HUMANIGL, IGLV3-22, V2-15Ig lambda chainP0CG06ratio: 1.806
A8364XLV605_HUMANIGL, IGLV3-22, V2-15Ig lambda chainP0CG05ratio: 1.806
A1600XC1R_HUMANC1RComplement C1r subcomponentP00736ratio: 1.816
A0098XVINC_HUMANVCLVinculinP18206-2ratio: 1.825
A8243XHV312_HUMANIGH, HuVH8B VH, scFvIg heavy chain V-III regionP01768ratio: 1.833
A815BXAPOD_HUMANAPODApolipoprotein D precursorP05090ratio: 1.860
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP01613ratio: 1.866
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP01622ratio: 1.872
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP01620ratio: 1.872
A8364XLV605_HUMANIGL, IGLV3-22, V2-15Ig lambda chainP01701ratio: 1.878
A4646XCD9_HUMANCD9, BTCC-1, MIC3CD9 antigenA6NNI4ratio: 1.949
A648CXTTHY_HUMANTTR, PALB, TBPATransthyretin precursorP02766ratio: 1.958
A742CXA2GL_HUMANLRG1, LRGLeucine-rich alpha-2-glycoprotein precursorP02750ratio: 1.962
A1175XLRP1_HUMANLRP, LRP1, A2MRProlow-density lipoprotein receptor-related protein 1Q07954ratio: 1.974
A1623XCO6_HUMANC6Complement component C6P13671ratio: 1.975
A1844XHBD_HUMANHBDHemoglobin delta chainP02042ratio: 1.980
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP18135ratio: 2.013
A1538XFA12_HUMANF12Coagulation factor XIIP00748ratio: 2.065
A7184XNSUN4_HUMANNSUN4Putative Methyltransferase NSUN4Q96CB9-2ratio: 2.086
A1500XFA10_HUMANF10Coagulation factor X precursorP00742ratio: 2.107
A0524XPROF1_HUMANPFN1Profilin IP07737ratio: 2.109
A8274XIGLL1_HUMANIGLL1, IGL1, IGLJ14.1Immunoglobulin lambda-like polypeptide 1 precursorA0M8Q6ratio: 2.114
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP06312ratio: 2.154
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP01619ratio: 2.160
A8243XHV312_HUMANIGH, HuVH8B VH, scFvIg heavy chain V-III regionP01769ratio: 2.193
A6053XCHLE_HUMANBCHE, CHE1Butyrylcholine esteraseF8WF14ratio: 2.211
B0119XAB12B_HUMANABHD12BAbhydrolase domain-containing protein 12BQ7Z5M8-2ratio: 2.242
A482AXH2A1H_HUMANHIST1H2AH, HIST1H2AIHistone H2A type 1-HQ96KK5ratio: 2.259
A1741XHBA_HUMANHBA1, HBA2, HBZHemoglobin subunit alphaP69905ratio: 2.279
A1627XCO8G_HUMANC8GComplement component C8 gamma chain precursorP07360ratio: 2.301
B7834XIQCE_HUMANIQCEIQ domain-containing protein EH7C427ratio: 2.306
A622AXJERKL_HUMANJRKLJerky protein homolog likeQ9Y4A0ratio: 2.318
A0643XPARVB_HUMANPARVB, CGI-56, CLINTBeta-parvinB0QYP6ratio: 2.348
A049AXPLF4_HUMANPF4, CXCL4, SCYB4Platelet factor 4 precursorP02776ratio: 2.363
A1708XC1QC_HUMANC1QC, C1QGComplement C1q subcomponent, C chain precursorP02747ratio: 2.394
A1580XLYAM1_HUMANL-selectin, SELL, LNHRL-selectin precursorP14151ratio: 2.399
A1176XAPOE_HUMANAPOEApolipoprotein E precursorP02649ratio: 2.436
A8243XHV312_HUMANIGH, HuVH8B VH, scFvIg heavy chain V-III regionP01779ratio: 2.477
B8006XJMY_HUMANJMYJunction-mediating and -regulatory proteinQ8N9B5-2ratio: 2.529
A1939XHV102_HUMANIGH, VH1, IGHG1Immunoglobulin G1 Fab heavy chain variable regionP01743ratio: 2.538
A1626XCO8B_HUMANC8BComplement component C8 beta chain precursorP07358ratio: 2.622
A813BXAPOC3_HUMANAPOC3Apolipoprotein C-III precursorP02656ratio: 2.633
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP01602ratio: 2.670
A088CXLBP_HUMANLBPLipopolysaccharide-binding protein precursorP18428ratio: 2.684
A6212XCRP_HUMANCRP, PTX1C-reactive protein precursorP02741ratio: 2.687
A1466XFINC_HUMANFN1, FNFibronectinP02751-14ratio: 2.769
B5290XF120B_HUMANFAM120B, CCPG, PGCC1Family with sequence similarity 120BQ96EK7-2ratio: 3.005
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP01611ratio: 3.073
A1596XC1QA_HUMANC1QA, DC33Complement C1q subcomponent, A chain precursorP02745ratio: 3.229
A079AXRAP1B_HUMANRAP1B, PNAS-140Ras-related protein Rap-1bP61224ratio: 3.233
A1521XVWF_HUMANVWF, F8VWFVon Willebrand factor precursorP04275ratio: 3.295
A5592XSAA4_HUMANSAA4, CSAASerum amyloid A-4 proteinP35542ratio: 3.676
A0999XCOF1_HUMANCFL1, CFLCofilin, non-muscle isoformE9PLJ3ratio: 3.677
A6042XCERU_HUMANCPCeruloplasmin precursorP00450ratio: 3.723
A487AXH2A2C_HUMANHIST2H2AC, H2AFQHistone H2A type 7Q16777ratio: 3.937
A309BXAPMAP_HUMANAPMAP, UNQ1869/PRO4305, UNQ1869Adipocyte plasma membrane-associated proteinQ9HDC9-2ratio: 4.014
A0160XCBL_HUMANC-CBL, CBL, CBL2E3 ubiquitin-protein ligase CBLP22681ratio: 4.243
B7638XIKBP1_HUMANIRAK1BP1Interleukin-1 receptor-associated kinase 1-binding protein 1U3KQ57ratio: 4.280
A6006XCBPN_HUMANCPN1, ACBPCarboxypeptidase N catalytic chain precursorP15169ratio: 4.341
A353CXRET4_HUMANRBP4, PRO2222, PRBPRetinol binding protein 4, plasmaQ5VY30ratio: 4.454
A8273XKV402_HUMANIGK, SDNK1, A30Ig kappa chainP04430ratio: 4.654
A9857XCXCL7_HUMANPPBP, CTAP3, CXCL7Platelet basic proteinP02775ratio: 4.725
A6644XGPX3_HUMANGPX3, GPXPGlutathione peroxidase 3P22352ratio: 5.475
A8364XLV605_HUMANIGL, IGLV3-22, V2-15Ig lambda chainP80748ratio: 6.104
A8268XIGHD_HUMANIGHD, VSIG6Ig delta chainP01880ratio: 6.836
A0361X1433Z_HUMANYWHAZ14-3-3 protein zeta/deltaP63104ratio: 7.104
A106AXRSU1_HUMANRSU1, RSP1Ras suppressor protein 1Q15404-2ratio: 7.304
A7972XTGM7_HUMANTGM7Protein-glutamine gamma-glutamyltransferase ZQ96PF1ratio: 7.664
A9747XSCLT1_HUMANSCLT1, SAP1Sodium channel and clathrin linker 1Q96NL6ratio: 8.879
A0748XGP1BA_HUMANGP1BA, GPIBPlatelet glycoprotein Ib alpha chain precursorP07359ratio: 9.181
A7386XPHLD_HUMANGPLD1, PIGPLD1, GPIPLDMPhosphatidylinositol-glycan-specific phospholipase D 1 precursorP80108ratio: 9.681
A1060XH4_HUMANHIST1H4A, HIST1H4B, HIST1H4CHistone H4P62805ratio: 11.158
A7776XSARDH_HUMANSARDH, DMGDHL1Sarcosine dehydrogenaseQ5SYV2ratio: 12.147
A8051XTRY3_HUMANPRSS3, mesotrypsinogen, PRSS4Trypsin III precursorB1AN99ratio: 15.816
A8229XHV106_HUMANIgG VH, IGHV7-81, IGHV1Ig heavy chain V-I regionP01742ratio: 15.859
A050CXKI16B_HUMANKIF16B, SNX23Kinesin-like protein KIF16BJ3QSY7ratio: 21.895
A989BXFRIL_HUMANFTL, FTLvariantFerritin light chainP02792ratio: 138.861
A2052XEP400_HUMANEP400, CAGH32, TNRC12E1A-binding protein p400Q96L91-3ratio: 161.524

Compile date 02-09-2018© C/VD project