cvd-logocvd - Molecule ID B1086

geneASCL1, ASH1, BHLHA46
nameAchaete-scute homolog 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ASCL1_HUMANP50553ENSG00000139352429Hs.703025100790

Functions and classifications

GOC:neuronal cell body, C:nucleus, F:double-stranded DNA binding, F:E-box binding, F:sequence-specific DNA binding, F:sequence-specific DNA binding transcription factor activity, F:transcription factor binding transcription factor activity, P:adrenal chromaffin cell differentiation, P:carotid body glomus cell differentiation, P:cellular response to magnetism, P:central nervous system neuron development, P:cerebral cortex development, P:cerebral cortex GABAergic interneuron differentiation, P:forebrain neuron differentiation, P:lung epithelial cell differentiation, P:lung neuroendocrine cell differentiation, P:musculoskeletal movement, spinal reflex action, P:negative regulation of apoptotic process, P:negative regulation of neuron differentiation, P:negative regulation of transcription, DNA-templated, P:neuroblast fate determination, P:neuroblast proliferation, P:neuron fate specification, P:neuron migration, P:noradrenergic neuron development, P:noradrenergic neuron fate commitment, P:Notch signaling pathway, P:olfactory pit development, P:oligodendrocyte development, P:pattern specification process, P:positive regulation of cell cycle, P:positive regulation of neural precursor cell proliferation, P:positive regulation of neurogenesis, P:positive regulation of neuron apoptotic process, P:positive regulation of neuron differentiation, P:positive regulation of Notch signaling pathway, P:positive regulation of transcription from RNA polymerase II promoter, P:regulation of timing of subpallium neuron differentiation, P:response to epidermal growth factor, P:response to folic acid, P:response to lithium ion, P:response to retinoic acid, P:spinal cord association neuron differentiation, P:spinal cord oligodendrocyte cell fate specification, P:stomach neuroendocrine cell differentiation, P:subpallium neuron fate commitment, P:sympathetic ganglion development, P:transcription, DNA-templated, P:vestibular nucleus development, P:negative regulation of transcription, DNA-dependent, P:regulation of cell proliferation, P:response to epidermal growth factor stimulus, P:sympathetic nervous system development, P:transcription, DNA-dependent
UniProtAcetylation, Activator, Complete proteome, Developmental protein, Differentiation, DNA-binding, Neurogenesis, Nucleus, Polymorphism, Reference proteome, Transcription, Transcription regulation
PADBTF: transcription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseP-valueDetectionPubMed/DOI
Exp17106732Homo sapiens12heartendocardiumDCMi (Inflammatory dilated cardiomyopathy (DCMi))5.32E-04Gene-array17106732

Compile date 02-09-2018© C/VD project