cvd-logocvd - Molecule ID A8645

geneADAP1, CENTA1
nameCentaurin, alpha 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADAP1_HUMANO75689ENSG0000010596311033Hs.602573608114

Functions and classifications

GOC:cell periphery, C:cytosol, C:lamellipodium, C:nucleus, C:ruffle, F:ATP binding, F:DNA binding, F:metal ion binding, F:nucleoside diphosphate kinase activity, F:protein histidine kinase activity, F:sequence-specific DNA binding transcription factor activity, P:cell adhesion, P:CTP biosynthetic process, P:GTP biosynthetic process, P:integrin-mediated signaling pathway, P:negative regulation of apoptotic process, P:nucleobase-containing small molecule interconversion, P:nucleoside triphosphate biosynthetic process, P:peptidyl-histidine phosphorylation, P:positive regulation of epithelial cell proliferation, P:positive regulation of keratinocyte differentiation, P:positive regulation of transcription from RNA polymerase II promoter, P:transcription, DNA-templated, P:UTP biosynthetic process, C:cytoplasm, C:centrosome, C:intermediate filament, C:mitochondrion, C:perinuclear region of cytoplasm, P:lactation, P:negative regulation of myeloid leukocyte differentiation, P:response to cAMP, P:response to drug, P:transcription, DNA-dependent, C:centrosome
UniProt3D-structure, Acetylation, Complete proteome, Cytoplasm, GTPase activation, Metal-binding, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Zinc, Zinc-finger
PADBTF: transcription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19059264Homo sapiens31bloodmonocytes and T-helper cellsAtherosclerosis (Coronary Atherosclerosis)1.209<0.05Gene-array19059264
Exp21804111Mus musculus9aorta CAD (Coronary artery disease (CAD))1.612<0.05Gene-array21804111
Exp21868699aMus musculus20macrophages Atherosclerosis (Atherosclerosis)1.142<0.05Gene-array21868699
Exp21868699bMus musculus40aorta and macrophages CAD (Coronary artery disease (CAD))0.904<0.05Gene-array21868699
Exp24082102Mus musculus88heartwholeCAD (Coronary artery disease (CAD))1.379<0.05Gene-array24082102
Exp24530965Homo sapiens23bloodmononuclear cells (PBMCs)CAD (Familial Hypercholesterolemia and Coronary artery disease (CAD))0.730<0.05Gene-array24530965
Exp25835000Homo sapiens31macrophages CAD (Coronary artery disease (CAD))0.895<0.05Gene-array25835000
Exp27142736Mus musculus12liver CAD (Coronary artery disease (CAD))0.538<0.05Gene-array27142736

Compile date 02-09-2018© C/VD project