cvd-logocvd - Molecule ID A8369

geneA1A, SERPINA1, AAT
nameAlpha-1-antitrypsin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
A1AT_HUMANP01009ENSG000001972495265Hs.525557107400, 613490

Functions and classifications

GOC:endoplasmic reticulum, C:extracellular space, C:platelet alpha granule lumen, C:proteinaceous extracellular matrix, F:serine-type endopeptidase inhibitor activity, P:acute-phase response, P:platelet activation, P:platelet degranulation, P:regulation of proteolysis, C:endoplasmic reticulum, C:extracellular space, C:platelet alpha granule lumen, C:proteinaceous extracellular matrix, F:serine-type endopeptidase inhibitor activity, P:acute-phase response, P:platelet activation, P:platelet degranulation, P:regulation of proteolysis
UniProt3D-structure, Acute phase, Alternative splicing, Blood coagulation, Complete proteome, Direct protein sequencing, Endoplasmic reticulum, Extracellular matrix, Glycoprotein, Hemostasis, Polymorphism, Protease inhibitor, Reference proteome, Secreted, Serine protease inhibitor, Signal
PADBINH: inhibitor (protease, kinase, other enzymes, pathways)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21417265Homo sapiens17heartmyocardiumDCM (Dilated cardiomyopathy)0.6000.008LC-MS/MS21417265
Exp22276806Homo sapiens16aortavalvesStenosis (Aortic stenosis)1.5040.02561MALDI-TOF/TOF22276806
Exp22276806Homo sapiens16aortavalvesStenosis (Aortic stenosis)1.7290.001521MALDI-TOF/TOF22276806
Exp22276806Homo sapiens16aortavalvesStenosis (Aortic stenosis)2.9610.0008152MALDI-TOF/TOF22276806
Exp25668619Homo sapiens10urinewholeCAD (Stable Coronary Artery Disease)1.410<0.05nanoLC-ESI-MS/MS25668619
Exp27234505Homo sapiens35bloodplasmaMI (Myocardial Ischemic Injury)0.829<0.05LC-MS/MS27234505

Compile date 02-09-2018© C/VD project