cvd-logocvd - Molecule ID A813B

geneAPOC3
nameApolipoprotein C-III precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOC3_HUMANP02656ENSG00000110245345Hs.73849107720, 614028

Functions and classifications

GOC:chylomicron, C:early endosome, C:intermediate-density lipoprotein particle, C:spherical high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:cholesterol binding, F:lipase inhibitor activity, F:phospholipid binding, P:cellular response to glucose stimulus, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:chylomicron remnant clearance, P:G-protein coupled receptor signaling pathway, P:high-density lipoprotein particle remodeling, P:inflammatory response, P:lipoprotein metabolic process, P:lipoprotein transport, P:negative regulation of cholesterol import, P:negative regulation of fatty acid biosynthetic process, P:negative regulation of high-density lipoprotein particle clearance, P:negative regulation of lipoprotein lipase activity, P:negative regulation of low-density lipoprotein particle clearance, P:negative regulation of receptor-mediated endocytosis, P:negative regulation of triglyceride catabolic process, P:negative regulation of very-low-density lipoprotein particle clearance, P:negative regulation of very-low-density lipoprotein particle remodeling, P:phospholipid efflux, P:phototransduction, visible light, P:regulation of Cdc42 protein signal transduction, P:response to drug, P:response to nutrient, P:response to peptide hormone, P:retinoid metabolic process, P:reverse cholesterol transport, P:small molecule metabolic process, P:triglyceride catabolic process, P:triglyceride homeostasis, P:triglyceride mobilization, P:very-low-density lipoprotein particle assembly, C:extracellular region, F:lipid binding, P:lipid transport, C:extracellular space, C:chylomicron, P:very-low-density lipoprotein particle assembly, C:chylomicron, C:early endosome, C:intermediate-density lipoprotein particle, C:spherical high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:cholesterol binding, F:lipase inhibitor activity, F:phospholipid binding, P:cellular response to glucose stimulus, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:chylomicron remnant clearance, P:G-protein coupled receptor signaling pathway, P:high-density lipoprotein particle remodeling, P:inflammatory response, P:lipoprotein metabolic process, P:lipoprotein transport, P:negative regulation of cholesterol import, P:negative regulation of fatty acid biosynthetic process, P:negative regulation of high-density lipoprotein particle clearance, P:negative regulation of lipoprotein lipase activity, P:negative regulation of low-density lipoprotein particle clearance, P:negative regulation of receptor-mediated endocytosis, P:negative regulation of triglyceride catabolic process, P:negative regulation of very-low-density lipoprotein particle clearance, P:negative regulation of very-low-density lipoprotein particle remodeling, P:phospholipid efflux, P:phototransduction, visible light, P:regulation of Cdc42 protein signal transduction, P:response to drug, P:response to nutrient, P:response to peptide hormone, P:retinoid metabolic process, P:reverse cholesterol transport, P:small molecule metabolic process, P:triglyceride catabolic process, P:triglyceride homeostasis, P:triglyceride mobilization, P:very-low-density lipoprotein particle assembly, C:extracellular region, F:lipid binding, P:lipid transport, C:extracellular space, C:chylomicron, P:very-low-density lipoprotein particle assembly
UniProt3D-structure, Chylomicron, Complete proteome, Direct protein sequencing, Disease mutation, Glycoprotein, Lipid degradation, Lipid metabolism, Lipid transport, Polymorphism, Reference proteome, Secreted, Sialic acid, Signal, Transport, VLDL, Lipoprotein
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21681990bMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)0.440<0.05MALDI-TOF/TOF21681991
Exp27234505Homo sapiens35bloodplasmaMI (Myocardial Ischemic Injury)2.633<0.05LC-MS/MS27234505

Compile date 02-09-2018© C/VD project