cvd-logocvd - Molecule ID A812B

geneAPOC1, APOC1B
nameApolipoprotein C-I precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOC1_HUMANP02654ENSG00000130208341Hs.110675107710

Functions and classifications

GOC:chylomicron, C:endoplasmic reticulum, C:high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:fatty acid binding, F:phosphatidylcholine binding, F:phosphatidylcholine-sterol O-acyltransferase activator activity, F:phospholipase inhibitor activity, P:cholesterol efflux, P:cholesterol metabolic process, P:chylomicron remnant clearance, P:high-density lipoprotein particle remodeling, P:lipid metabolic process, P:lipoprotein metabolic process, P:negative regulation of cholesterol transport, P:negative regulation of fatty acid biosynthetic process, P:negative regulation of lipoprotein lipase activity, P:negative regulation of phosphatidylcholine catabolic process, P:negative regulation of receptor-mediated endocytosis, P:negative regulation of very-low-density lipoprotein particle clearance, P:phospholipid efflux, P:positive regulation of cholesterol esterification, P:triglyceride metabolic process, P:very-low-density lipoprotein particle assembly, P:very-low-density lipoprotein particle clearance, C:extracellular region, P:regulation of lipid transport, C:chylomicron, C:endoplasmic reticulum, C:high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:fatty acid binding, F:phosphatidylcholine binding, F:phosphatidylcholine-sterol O-acyltransferase activator activity, F:phospholipase inhibitor activity, P:cholesterol efflux, P:cholesterol metabolic process, P:chylomicron remnant clearance, P:high-density lipoprotein particle remodeling, P:lipid metabolic process, P:lipoprotein metabolic process, P:negative regulation of cholesterol transport, P:negative regulation of fatty acid biosynthetic process, P:negative regulation of lipoprotein lipase activity, P:negative regulation of phosphatidylcholine catabolic process, P:negative regulation of receptor-mediated endocytosis, P:negative regulation of very-low-density lipoprotein particle clearance, P:phospholipid efflux, P:positive regulation of cholesterol esterification, P:triglyceride metabolic process, P:very-low-density lipoprotein particle assembly, P:very-low-density lipoprotein particle clearance, C:extracellular region, P:regulation of lipid transport
UniProt3D-structure, Complete proteome, Direct protein sequencing, Lipid transport, Polymorphism, Reference proteome, Secreted, Signal, Transport, VLDL, Lipoprotein
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21681990aMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)2.200<0.05MALDI-TOF/TOF21681990
Exp21681990cMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)2.600<0.05ESI-LTQ(PQD)-Orbitrap21681991
Exp27234505Homo sapiens35bloodplasmaMI (Myocardial Ischemic Injury)0.467<0.05LC-MS/MS27234505
Exp27350024a1Homo sapienspool; 2bloodplasmaCAD (Coronary artery disease (CAD) Discovery Phase, 1st set (113:117), triple vessel disease)0.7840.0161MALDI TOF/TOF27350024
Exp27350024a4Homo sapienspool; 2bloodplasmaCAD (Coronary artery disease (CAD) Discovery Phase, 4th set (114:116), double vessel disease)0.2890.0057MALDI TOF/TOF27350024
Exp27350024cHomo sapiens506bloodplasmaCAD (Coronary artery disease (CAD) Validation Phase)0.825<0.0001ELISA27350024

Compile date 02-09-2018© C/VD project