cvd-logocvd - Molecule ID A810B

geneAPOA4, ApoA-IV, APOA-IV
nameApolipoprotein A-IV precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOA4_HUMANP06727ENSG00000110244337Hs.1247107690

Functions and classifications

GOC:chylomicron, C:cytosol, C:early endosome, C:endoplasmic reticulum lumen, C:high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:antioxidant activity, F:cholesterol transporter activity, F:copper ion binding, F:phosphatidylcholine binding, F:phosphatidylcholine-sterol O-acyltransferase activator activity, F:protein homodimerization activity, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:chylomicron assembly, P:chylomicron remodeling, P:high-density lipoprotein particle remodeling, P:hydrogen peroxide catabolic process, P:innate immune response in mucosa, P:leukocyte cell-cell adhesion, P:lipoprotein metabolic process, P:multicellular organismal lipid catabolic process, P:negative regulation of plasma lipoprotein particle oxidation, P:phosphatidylcholine metabolic process, P:phospholipid efflux, P:phototransduction, visible light, P:positive regulation of cholesterol esterification, P:positive regulation of fatty acid biosynthetic process, P:positive regulation of lipoprotein lipase activity, P:positive regulation of triglyceride catabolic process, P:regulation of cholesterol transport, P:regulation of intestinal cholesterol absorption, P:removal of superoxide radicals, P:response to lipid hydroperoxide, P:response to stilbenoid, P:retinoid metabolic process, P:reverse cholesterol transport, P:very-low-density lipoprotein particle remodeling, C:extracellular region, F:lipid binding, P:lipid transport, C:chylomicron, P:very-low-density lipoprotein particle remodeling, C:chylomicron, C:cytosol, C:early endosome, C:endoplasmic reticulum lumen, C:high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:antioxidant activity, F:cholesterol transporter activity, F:copper ion binding, F:phosphatidylcholine binding, F:phosphatidylcholine-sterol O-acyltransferase activator activity, F:protein homodimerization activity, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:chylomicron assembly, P:chylomicron remodeling, P:high-density lipoprotein particle remodeling, P:hydrogen peroxide catabolic process, P:innate immune response in mucosa, P:leukocyte cell-cell adhesion, P:lipoprotein metabolic process, P:multicellular organismal lipid catabolic process, P:negative regulation of plasma lipoprotein particle oxidation, P:phosphatidylcholine metabolic process, P:phospholipid efflux, P:phototransduction, visible light, P:positive regulation of cholesterol esterification, P:positive regulation of fatty acid biosynthetic process, P:positive regulation of lipoprotein lipase activity, P:positive regulation of triglyceride catabolic process, P:regulation of cholesterol transport, P:regulation of intestinal cholesterol absorption, P:removal of superoxide radicals, P:response to lipid hydroperoxide, P:response to stilbenoid, P:retinoid metabolic process, P:reverse cholesterol transport, P:very-low-density lipoprotein particle remodeling, C:extracellular region, F:lipid binding, P:lipid transport, C:chylomicron, P:very-low-density lipoprotein particle remodeling
UniProt3D-structure, Chylomicron, Complete proteome, HDL, Lipid transport, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Secreted, Signal, Transport, Lipoprotein
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21681990aMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)1.900<0.05MALDI-TOF/TOF21681990
Exp21681990bMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)1.700<0.05MALDI-TOF/TOF21681991
Exp27234505Homo sapiens35bloodplasmaMI (Myocardial Ischemic Injury)0.407<0.05LC-MS/MS27234505
Exp27350024a1Homo sapienspool; 2bloodplasmaCAD (Coronary artery disease (CAD) Discovery Phase, 1st set (113:117), triple vessel disease)0.727<0.0001MALDI TOF/TOF27350024
Exp27350024a2Homo sapienspool; 2bloodplasmaCAD (Coronary artery disease (CAD) Discovery Phase, 2nd set (114:118), triple vessel disease)0.8250.0001MALDI TOF/TOF27350024
Exp27350024a3Homo sapienspool; 2bloodplasmaCAD (Coronary artery disease (CAD) Discovery Phase, 3rd set (115:119), triple vessel disease)0.6900.0189MALDI TOF/TOF27350024
Exp27350024a5Homo sapienspool; 2bloodplasmaCAD (Coronary artery disease (CAD) Discovery Phase, 5th set (115:117), double vessel disease)0.747<0.0001MALDI TOF/TOF27350024
Exp27350024bHomo sapiens40bloodplasmaCAD (Coronary artery disease (CAD) Verification Phase)0.4690.0045ELISA27350024
Exp27350024cHomo sapiens506bloodplasmaCAD (Coronary artery disease (CAD) Validation Phase)0.800<0.0001ELISA27350024

Compile date 02-09-2018© C/VD project