cvd-logocvd - Molecule ID A809B

geneAPOA2
nameApolipoprotein A-II precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOA2_HUMANP02652ENSG00000158874336Hs.237658107670

Functions and classifications

GOC:chylomicron, C:cytosol, C:early endosome, C:endoplasmic reticulum lumen, C:spherical high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:cholesterol binding, F:cholesterol transporter activity, F:high-density lipoprotein particle binding, F:lipase inhibitor activity, F:lipid transporter activity, F:phosphatidylcholine binding, F:phosphatidylcholine-sterol O-acyltransferase activator activity, F:protein homodimerization activity, P:acute inflammatory response, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:diacylglycerol catabolic process, P:high-density lipoprotein particle assembly, P:high-density lipoprotein particle clearance, P:high-density lipoprotein particle remodeling, P:lipoprotein metabolic process, P:low-density lipoprotein particle remodeling, P:negative regulation of cholesterol import, P:negative regulation of cholesterol transporter activity, P:negative regulation of cytokine secretion involved in immune response, P:negative regulation of lipase activity, P:negative regulation of lipid catabolic process, P:negative regulation of very-low-density lipoprotein particle remodeling, P:organ regeneration, P:peptidyl-methionine modification, P:phosphatidylcholine biosynthetic process, P:phospholipid catabolic process, P:phospholipid efflux, P:phototransduction, visible light, P:positive regulation of cholesterol esterification, P:positive regulation of interleukin-8 biosynthetic process, P:positive regulation of lipid catabolic process, P:protein folding, P:protein oxidation, P:regulation of intestinal cholesterol absorption, P:regulation of protein stability, P:response to drug, P:response to estrogen, P:response to glucocorticoid, P:response to glucose, P:retinoid metabolic process, P:reverse cholesterol transport, P:triglyceride metabolic process, P:triglyceride-rich lipoprotein particle remodeling, P:viral process, P:response to estrogen stimulus, P:response to glucocorticoid stimulus, P:response to glucose stimulus, P:virus-host interaction, C:chylomicron, C:cytosol, C:early endosome, C:endoplasmic reticulum lumen, C:spherical high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:cholesterol binding, F:cholesterol transporter activity, F:high-density lipoprotein particle binding, F:lipase inhibitor activity, F:lipid transporter activity, F:phosphatidylcholine binding, F:phosphatidylcholine-sterol O-acyltransferase activator activity, F:protein homodimerization activity, P:acute inflammatory response, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:diacylglycerol catabolic process, P:high-density lipoprotein particle assembly, P:high-density lipoprotein particle clearance, P:high-density lipoprotein particle remodeling, P:lipoprotein metabolic process, P:low-density lipoprotein particle remodeling, P:negative regulation of cholesterol import, P:negative regulation of cholesterol transporter activity, P:negative regulation of cytokine secretion involved in immune response, P:negative regulation of lipase activity, P:negative regulation of lipid catabolic process, P:negative regulation of very-low-density lipoprotein particle remodeling, P:organ regeneration, P:peptidyl-methionine modification, P:phosphatidylcholine biosynthetic process, P:phospholipid catabolic process, P:phospholipid efflux, P:phototransduction, visible light, P:positive regulation of cholesterol esterification, P:positive regulation of interleukin-8 biosynthetic process, P:positive regulation of lipid catabolic process, P:protein folding, P:protein oxidation, P:regulation of intestinal cholesterol absorption, P:regulation of protein stability, P:response to drug, P:response to estrogen, P:response to glucocorticoid, P:response to glucose, P:retinoid metabolic process, P:reverse cholesterol transport, P:triglyceride metabolic process, P:triglyceride-rich lipoprotein particle remodeling, P:viral process, P:response to estrogen stimulus, P:response to glucocorticoid stimulus, P:response to glucose stimulus, P:virus-host interaction
UniProt3D-structure, Cleavage on pair of basic residues, Complete proteome, Direct protein sequencing, Disulfide bond, Glycoprotein, HDL, Host-virus interaction, Lipid transport, Oxidation, Phosphoprotein, Pyrrolidone carboxylic acid, Reference proteome, Secreted, Signal, Transport, Lipoprotein
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21681990aMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)0.200<0.05MALDI-TOF/TOF21681990
Exp21681990bMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)0.170<0.05MALDI-TOF/TOF21681991
Exp27234505Homo sapiens35bloodplasmaMI (Myocardial Ischemic Injury)0.473<0.05LC-MS/MS27234505

Compile date 02-09-2018© C/VD project