cvd-logocvd - Molecule ID A7979

geneACAA2
nameAcetyl-CoA acyltransferase 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
THIM_HUMANP42765ENSG0000016731510449Hs.200136604770

Functions and classifications

GOC:mitochondrial inner membrane, C:mitochondrion, F:acetyl-CoA C-acyltransferase activity, P:cholesterol biosynthetic process, P:fatty acid metabolic process, P:negative regulation of mitochondrial outer membrane permeabilization, F:transferase activity, transferring acyl groups other than amino-acyl groups, P:acetyl-CoA metabolic process, P:fatty acid beta-oxidation, P:negative regulation of apoptotic process, C:mitochondrial inner membrane, C:mitochondrion, F:acetyl-CoA C-acyltransferase activity, P:cholesterol biosynthetic process, P:fatty acid metabolic process, P:negative regulation of mitochondrial outer membrane permeabilization, F:transferase activity, transferring acyl groups other than amino-acyl groups, P:acetyl-CoA metabolic process, P:fatty acid beta-oxidation, P:negative regulation of apoptotic process
UniProtAcetylation, Acyltransferase, Complete proteome, Direct protein sequencing, Fatty acid metabolism, Lipid metabolism, Mitochondrion, Phosphoprotein, Polymorphism, Reference proteome, Transferase, Transit peptide
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp15769906aHomo sapiens19heartmyocardiumNICM (Pre-LVAD, nonischemic cardiomyopathy) 9.71E-07Gene-array15769906
Exp19059264Homo sapiens31bloodmonocytes and T-helper cellsAtherosclerosis (Coronary Atherosclerosis)0.930<0.05Gene-array19059264
Exp21417265Homo sapiens17heartmyocardiumDCM (Dilated cardiomyopathy)0.7000.00008205LC-MS/MS21417265
Exp21804111Mus musculus9aorta CAD (Coronary artery disease (CAD))1.274<0.05Gene-array21804111
Exp21868699aMus musculus20macrophages Atherosclerosis (Atherosclerosis)0.906<0.05Gene-array21868699
Exp21868699bMus musculus40aorta and macrophages CAD (Coronary artery disease (CAD))0.620<0.05Gene-array21868699
Exp24082102Mus musculus88heartwholeCAD (Coronary artery disease (CAD))1.277<0.05Gene-array24082102
Exp24530965Homo sapiens23bloodmononuclear cells (PBMCs)CAD (Familial Hypercholesterolemia and Coronary artery disease (CAD))1.273<0.05Gene-array24530965
Exp24859250Homo sapiens20bloodplasmaCHD (Coronary heart disease (CHD))1.4210.038643nanoLC-MS/MS24859250
Exp25835000Homo sapiens31macrophages CAD (Coronary artery disease (CAD))1.324<0.05Gene-array25835000
Exp27142736Mus musculus12liver CAD (Coronary artery disease (CAD))1.254<0.05Gene-array27142736

Compile date 02-09-2018© C/VD project