cvd-logocvd - Molecule ID A783B

geneABCG1, ABC8, WHT1
nameATP-binding cassette, sub-family G, member 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ABCG1_HUMANP45844ENSG000001601799619Hs.124649603076

Functions and classifications

GOC:endoplasmic reticulum membrane, C:external side of plasma membrane, C:Golgi apparatus, C:Golgi membrane, C:integral component of plasma membrane, C:mitochondrion, C:recycling endosome, F:ADP binding, F:ATP binding, F:cholesterol binding, F:cholesterol transporter activity, F:glycoprotein transporter activity, F:phospholipid binding, F:phospholipid transporter activity, F:protein homodimerization activity, F:sterol-transporting ATPase activity, F:toxin transporter activity, P:amyloid precursor protein catabolic process, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:detection of hormone stimulus, P:glycoprotein transport, P:high-density lipoprotein particle remodeling, P:intracellular cholesterol transport, P:lipoprotein metabolic process, P:low-density lipoprotein particle remodeling, P:negative regulation of cholesterol storage, P:negative regulation of macrophage derived foam cell differentiation, P:phospholipid efflux, P:phospholipid homeostasis, P:positive regulation of cholesterol biosynthetic process, P:positive regulation of cholesterol efflux, P:regulation of cholesterol esterification, P:regulation of transcription, DNA-templated, P:response to high density lipoprotein particle, P:response to lipid, P:reverse cholesterol transport, F:ATPase activity, P:ATP catabolic process, C:membrane, P:transport, C:external side of plasma membrane, P:negative regulation of lipid storage, C:integral to plasma membrane, P:regulation of transcription, DNA-dependent, P:response to high density lipoprotein particle stimulus, C:integral to membrane, C:integral to membrane, C:endoplasmic reticulum membrane, C:external side of plasma membrane, C:Golgi apparatus, C:Golgi membrane, C:integral component of plasma membrane, C:mitochondrion, C:recycling endosome, F:ADP binding, F:ATP binding, F:cholesterol binding, F:cholesterol transporter activity, F:glycoprotein transporter activity, F:phospholipid binding, F:phospholipid transporter activity, F:protein homodimerization activity, F:sterol-transporting ATPase activity, F:toxin transporter activity, P:amyloid precursor protein catabolic process, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:detection of hormone stimulus, P:glycoprotein transport, P:high-density lipoprotein particle remodeling, P:intracellular cholesterol transport, P:lipoprotein metabolic process, P:low-density lipoprotein particle remodeling, P:negative regulation of cholesterol storage, P:negative regulation of macrophage derived foam cell differentiation, P:phospholipid efflux, P:phospholipid homeostasis, P:positive regulation of cholesterol biosynthetic process, P:positive regulation of cholesterol efflux, P:regulation of cholesterol esterification, P:regulation of transcription, DNA-templated, P:response to high density lipoprotein particle, P:response to lipid, P:reverse cholesterol transport, F:ATPase activity, P:ATP catabolic process, C:membrane, P:transport, C:external side of plasma membrane, P:negative regulation of lipid storage, C:integral to plasma membrane, P:regulation of transcription, DNA-dependent, P:response to high density lipoprotein particle stimulus, C:integral to membrane, C:integral to membrane
UniProtAlternative splicing, ATP-binding, Complete proteome, Endoplasmic reticulum, Golgi apparatus, Lipid transport, Lipoprotein, Membrane, Mitochondrion, Nucleotide-binding, Palmitate, Polymorphism, Reference proteome, Transmembrane, Transmembrane helix, Transport
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19059264Homo sapiens31bloodmonocytes and T-helper cellsAtherosclerosis (Coronary Atherosclerosis)1.115<0.05Gene-array19059264
Exp21804111Mus musculus9aorta CAD (Coronary artery disease (CAD))0.829<0.05Gene-array21804111
Exp21868699aMus musculus20macrophages Atherosclerosis (Atherosclerosis)1.166<0.05Gene-array21868699
Exp21868699bMus musculus40aorta and macrophages CAD (Coronary artery disease (CAD))1.177<0.05Gene-array21868699
Exp24082102Mus musculus88heartwholeCAD (Coronary artery disease (CAD))1.169<0.05Gene-array24082102
Exp24339868Homo sapiens17heartapex left ventricleDCM (Dilated cardiomyopathy (DCM)) 4.15E-04Gene-array24339868
Exp24530965Homo sapiens23bloodmononuclear cells (PBMCs)CAD (Familial Hypercholesterolemia and Coronary artery disease (CAD))0.521<0.05Gene-array24530965
Exp25835000Homo sapiens31macrophages CAD (Coronary artery disease (CAD))1.175<0.05Gene-array25835000
Exp27142736Mus musculus12liver CAD (Coronary artery disease (CAD))1.290<0.05Gene-array27142736

Compile date 02-09-2018© C/VD project